Changshan Wang

Atsushi Iwama6
Makiko Mochizuki-Kashio4
Yaeko Nakajima-Takagi3
Hiromitsu Nakauchi3
6Atsushi Iwama
4Makiko Mochizuki-Kashio
3Yaeko Nakajima-Takagi
3Hiromitsu Nakauchi
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Among mammals, only eutherians and marsupials are viviparous and have genomic imprinting that leads to parent-of-origin-specific differential gene expression. We used comparative analysis to investigate the origin of genomic imprinting in mammals. PEG10 (paternally expressed 10) is a retrotransposon-derived imprinted gene that has an essential role for the(More)
Responding to various stimuli is indispensable for the maintenance of homeostasis. The downregulation of ribosomal RNA (rRNA) transcription is one of the mechanisms involved in the response to stimuli by various cellular processes, such as cell cycle arrest and apoptosis. Cell differentiation is caused by intra- and extracellular stimuli and is associated(More)
  • Taito Nishino, Changshan Wang, Makiko Mochizuki-Kashio, Mitsujiro Osawa, Hiromitsu Nakauchi, Atsushi Iwama
  • 2001
BACKGROUND Human cord blood (hCB) is the main source of hematopoietic stem and progenitor cells (HSCs/PCs) for transplantation. Efforts to overcome relative shortages of HSCs/PCs have led to technologies to expand HSCs/PCs ex vivo. However, methods suitable for clinical practice have yet to be fully established. METHODOLOGY/PRINCIPAL FINDINGS In this(More)
  • Changshan Wang, Motohiko Oshima, Goro Sashida, Takahisa Tomioka, Nagisa Hasegawa, Makiko Mochizuki-Kashio +7 others
  • 2015
Precise understanding of radiation effects is critical to develop new modalities for the prevention and treatment of radiation-induced damage. We previously reported that non-lethal doses of X-ray irradiation induce DNA damage in human hematopoietic stem and progenitor cells (HSPCs) reconstituted in NOD/Shi-scid IL2rγnull (NOG) immunodeficient mice and(More)
  • Satoru Miyagi, Shuhei Koide, Atsunori Saraya, George R. Wendt, Motohiko Oshima, Takaaki Konuma +8 others
  • 2014
TIF1β is a transcriptional corepressor that recruits repressive chromatin modifiers to target genes. Its biological function and physiological targets in somatic stem cells remain largely unknown. Here, we show that TIF1β is essential for the maintenance of hematopoietic stem cells (HSCs). Deletion of Tif1b in mice induced active cycling and apoptosis of(More)
An optical interconnection architecture is proposed, which is based on optical ring and torus. The proposed optical interconnection network combines advantages of both ring and torus, e.g., simple node interface, constant node degree, better support for local communication and remote communication, wide bisection and good scalability etc. This architecture(More)
  • Satoru Miyagi, Shuhei Koide, Atsunori Saraya, George R Wendt, Motohiko Oshima, Takaaki Konuma +8 others
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited. SUMMARY TIF1b is a transcriptional corepressor that recruits repressive chromatin(More)
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