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BACKGROUND Specific immunotherapy (SIT) is the only curable remedy for allergic disorders currently; however, the underlying mechanism is not fully understood yet. This study aimed to elucidate the mechanism of SIT on suppressing TIM4 (T cell immunoglobulin mucin domain molecule 4) expression in dendritic cells (DCs) and modulating the skewed T helper 2(More)
BACKGROUND The association between sensitizations and severity of allergic diseases is controversial. OBJECTIVE This study was to investigate the association between severity of asthma and rhinitis and degree of specific allergic sensitization in allergic patients in China. METHOD A cross-sectional survey was performed in 6304 patients with asthma(More)
OBJECTIVE To detected the mechanism of allergic rhinitis associated with asthma with bioinformatics methods. METHOD GenMAPP software was used to analyze the expression profile of nasal mucosa of seasonal allergic rhinitis(SAR) and SAR associated with asthma of oligonucleotide microarray (Affymetrix HG-U133-plus2). One the first step,of differentially(More)
BACKGROUND Allergen sensitization is influenced by genetic and environmental factors; however, the factors related to sensitizations in patients with rhinitis and asthma in China are largely unknown. This study investigated the factors associated with allergen sensitizations in patients with asthma and rhinitis in China. METHODS A cross-sectional survey(More)
OBJECTIVE To dynamically analyze the change of xerostomia in patients with nasopharyngeal carcinoma after radiotherapy by DW MRI. METHODS Twenty-three nasopharyngeal carcinoma patients confirmed by pathology were enrolled. Male/Female: 19/4. The age was from 37 to 69 years. The patients were divided into two groups: G1, Dmean<26 Gy, G2, Dmean ≥ 26 Gy. All(More)
BACKGROUND Invasive fungal rhinosinusitis (IFRS) is a life-threatening inflammatory disease that affects immunocompromised patients, but animal models of the disease are scarce. This study aimed to develop an IFRS model in neutropenic rats. METHODS The model was established in three consecutive steps: unilateral nasal obstruction with Merocel sponges,(More)
OBJECTIVE To evaluate the effectiveness and usefulness of transnasal endoscopic surgery for the treatment of maxillary cysts. METHOD Transnasal endoscopic surgery was performed in 13 patients with maxillary cysts that extended to the maxillary sinus or the nasal bottom. Five patients had a radicular cyst, three patients had a dentigerous cyst, three(More)
OBJECTIVE To investigate the application of endoscopic nasal lateral wall dissection in lesions of the maxillary sinus. METHOD Ten hospitalized patients with the maxillary sinus lesions were treated with the endoscopic nasal lateral wall dissection. RESULT All 10 patients were unilateral invasion. Among them, 7 cases were inverted papilloma, 2 cases(More)