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A practical approach to asymmetric synthesis of dolastatin 10.
TLDR
A practical method to the key subunit Val-Dil has been established as an alternative synthetic route for the synthesis of this challenging chemical structure. Expand
Studies toward asymmetric synthesis of leiodelide A
An enantioselective route for oxazoline 4, a key fragment toward the asymmetric synthesis of leiodelide A, is described. We synthesized northern subunit 6 through a Julia–Lythgoe olefination andExpand
Zinc-Mediated Decarboxylative Alkylation of Gem-difluoroalkenes.
An efficient and mild zinc-mediated decarboxylative alkylation of gem-difluoroalkenes with N-hydroxyphthalimide (NHP) esters, to give monofluoroalkenes in moderate to excellent yields with highExpand
Diastereoconvergent synthesis of trans-5-hydroxy-6-substituted-2-piperidinones by addition-cyclization-deprotection process.
A diastereoselective one-pot approach to access trans-5-hydroxy-6-substituted-2-piperidinones by an addition-cyclization-deprotection process has been developed, in which the stereogenic center atExpand
Stereoselective Synthesis of Pyrido- and Pyrrolo[1,2- c][1,3]oxazin-1-ones via a Nucleophilic Addition-Cyclization Process of N, O-Acetal with Ynamides.
An efficient asymmetric approach to access functionalized pyrido- and pyrrolo[1,2- c][1,3]oxazin-1-ones has been developed through a nucleophilic addition-cyclization process of N, O-acetal withExpand
Divergent Method to trans-5-Hydroxy-6-alkynyl/alkenyl-2-piperidinones: Syntheses of (-)-Epiquinamide and (+)-Swainsonine.
An efficient diastereoselective approach to access trans-5-hydroxy-6-alkynyl/alkenyl-2-piperidinones has been developed through nucleophilic addition of α-chiral aldimines using alkynyl/alkenylExpand
Divergent Synthesis of Revised Apratoxin E, 30-epi-Apratoxin E, and 30S/30R-Oxoapratoxin E.
TLDR
The authors' alternative convergent assembly strategy was applied to the divergent synthesis of revised apratoxin E and its three analogues and ring-closing metathesis (RCM) was for the first time found to be an efficient strategy for the macrocyclization of apratoxins. Expand
Asymmetric Synthesis of Apratoxin E.
TLDR
An efficient method for asymmetric synthesis of apratoxin E 2 is described in this report, and pentafluorophenyl diphenylphosphinate was found to be an efficient condensation reagent for the macrocyclization. Expand
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