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Fragile X syndrome (FXS), the most common form of inherited mental retardation, is caused by the loss of functional fragile X mental retardation protein (FMRP). FMRP is an RNA-binding protein that can regulate the translation of specific mRNAs. Adult neurogenesis, a process considered important for neuroplasticity and memory, is regulated at multiple(More)
We use the method of layer potentials to study interior and exterior Dirichlet and Neumann problems for the Helmholtz equation (+k 2)u = 0 on a Lipschitz domain for all wave n umber k 2C with Imk0. Following the approach for the case of smooth boundary [3], we pursue as solution a single layer potential for Neumann problem or a double layer potential for(More)
  • Weixiang Guo, Li Zhang, Devin M. Christopher, Zhao-Qian Teng, Sarah R. Fausett, Changmei Liu +4 others
  • 2011
In adult mammalian brains, neurogenesis persists in the subventricular zone of the lateral ventricles (SVZ) and the dentate gyrus (DG) of the hippocampus. Although evidence suggest that adult neurogenesis in these two regions is subjected to differential regulation, the underlying mechanism is unclear. Here, we show that the RNA-binding protein FXR2(More)
  • Changmei Liu, Zhao-Qian Teng, Andrea L. McQuate, Emily M. Jobe, Christa C. Christ, Sergei J. von Hoyningen-Huene +6 others
  • 2013
BACKGROUND Epigenetic mechanisms, including DNA methylation, histone modification, and microRNAs, play pivotal roles in stem cell biology. Methyl-CpG binding protein 1 (MBD1), an important epigenetic regulator of adult neurogenesis, controls the proliferation and differentiation of adult neural stem/progenitor cells (aNSCs). We recently demonstrated that(More)
Ovarian cancers present a mild clinical course when diagnosed early but an aggressive pathway when diagnosed in the peri- and postmenopausal periods. However, the predictability of tumor progression is stochastic and is difficult to predict. In the present study, we hypothesized to examine the key pathways that are dysregulated to promote(More)
This study aims to investigate the correlation between the different characteristics of plaques, plasma level of homocysteine (Hcy), and gene polymorphism of Hcy metabolism-related enzyme. In this consecutive case–control study, we measured the plasma Hcy level using fluorescence biochemistry method and examined the gene polymorphism of Hcy(More)
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