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Methyl-CpG binding protein 1 (MBD1) regulates gene expression via a DNA methylation-mediated epigenetic mechanism. We have previously demonstrated that MBD1 deficiency impairs adult neural stem/progenitor cell (aNSC) differentiation and neurogenesis, but the underlying mechanism was unclear. Here, we show that MBD1 regulates the expression of several(More)
Fragile X syndrome (FXS), the most common form of inherited mental retardation, is caused by the loss of functional fragile X mental retardation protein (FMRP). FMRP is an RNA-binding protein that can regulate the translation of specific mRNAs. Adult neurogenesis, a process considered important for neuroplasticity and memory, is regulated at multiple(More)
Neurogenesis is defined as a process that includes the proliferation of neural stem/progenitor cells (NPCs) and the differentiation of these cells into new neurons that integrate into the existing neuronal circuitry. MicroRNAs (miRNAs) are a recently discovered class of small non-protein coding RNA molecules implicated in a wide range of diverse gene(More)
We use the method of layer potentials to study interior and exterior Dirichlet and Neumann problems for the Helmholtz equation (+k 2)u = 0 on a Lipschitz domain for all wave n umber k 2C with Imk0. Following the approach for the case of smooth boundary [3], we pursue as solution a single layer potential for Neumann problem or a double layer potential for(More)
Whether and how mechanisms intrinsic to stem cells modulate their proliferation and differentiation are two central questions in stem cell biology. Although exogenous basic fibroblast growth factor 2 (FGF-2/Fgf-2) is commonly used to expand adult neural stem/progenitor cells (NSPCs) in vitro, we do not yet understand the functional significance or the(More)
BACKGROUND Epigenetic mechanisms, including DNA methylation, histone modification, and microRNAs, play pivotal roles in stem cell biology. Methyl-CpG binding protein 1 (MBD1), an important epigenetic regulator of adult neurogenesis, controls the proliferation and differentiation of adult neural stem/progenitor cells (aNSCs). We recently demonstrated that(More)
In adult mammalian brains, neurogenesis persists in the subventricular zone of the lateral ventricles (SVZ) and the dentate gyrus (DG) of the hippocampus. Although evidence suggest that adult neurogenesis in these two regions is subjected to differential regulation, the underlying mechanism is unclear. Here, we show that the RNA-binding protein FXR2(More)
Ovarian cancers present a mild clinical course when diagnosed early but an aggressive pathway when diagnosed in the peri- and postmenopausal periods. However, the predictability of tumor progression is stochastic and is difficult to predict. In the present study, we hypothesized to examine the key pathways that are dysregulated to promote(More)
In this paper, we study the determination of the shape of an obstacle with rough boundary (not necessary Lipschitz) from its scattering amplitude. Following the technique used in paper [6], we obtain an extension of the local uniqueness result for Lipschitz obstacles to rougher ones. We also give a criterion to identify a ball in R 3 from its scattering(More)
In this paper, a joint user scheduling and beamforming method based on limited feedback is studied for a cognitive radio (CR) multi-user multi-input multi-output (MU-MIMO) network, where a large number of secondary users (SUs) coexist with a primary user (PU). In the proposed approach, secondary users feed precoding vector indices (PVIs) and signal to(More)