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Antiviral activity of Paulownia tomentosa against enterovirus 71 of hand, foot, and mouth disease.
TLDR
The effects of Paulownia against EV71 infection is validates and mechanistic insights on apigenin as an active compound for the antiviral activity of P. tomentosa against EV 71 infection are yielded. Expand
Curcumin is a biologically active copper chelator with antitumor activity.
TLDR
Curcumin antitumor effect to its copper chelation capability is demonstrated, which implicate copperChelation as a general mechanism for their action of some biologically active polyphenols like flavonoids. Expand
Chemical modifications of nucleic acid drugs and their delivery systems for gene‐based therapy
TLDR
This review focuses on current nucleic acid drugs and their formulation in clinical trials and on the market, including antisense oligonucleotide, siRNA, aptamer, and plasmid nucleic Acid drugs. Expand
Curcumin enhances cisplatin sensitivity of human NSCLC cell lines through influencing Cu-Sp1-CTR1 regulatory loop.
TLDR
The results demonstrated copper chelator curcumin enhances the benefits of platinum-containing chemotherapeutic agents and CTR1 could be a promising therapeutic target for non-small cell lung cancer treatment. Expand
Circular siRNAs for Reducing Off-Target Effects and Enhancing Long-Term Gene Silencing in Cells and Mice
TLDR
The present work synthesized a series of circular siRNAs by cyclizing two ends of a single-stranded RNA (sense or antisense strand) to construct circularSiRNAs that were more resistant to enzymatic degradation and achieved longer gene-silencing efficiency in mice with circular si RNAs than with linear siRNA. Expand
Suppression of IRG-1 Reduces Inflammatory Cell Infiltration and Lung Injury in Respiratory Syncytial Virus Infection by Reducing Production of Reactive Oxygen Species
ABSTRACT Respiratory syncytial virus (RSV) infection is a common cause of lower respiratory tract illness in infants and children. RSV is a negative-sense, single-strand RNA (ssRNA) virus that mainlyExpand
Multicolor Raman Beads for Multiplexed Tumor Cell and Tissue Imaging and in Vivo Tumor Spectral Detection.
TLDR
Polymeric nanoparticles with monomers containing alkyne, cyanide, azide, and carbon-deuterate were prepared as Raman-active nanomaterials (Raman beads) for bioimaging applications and targetable Raman beads anchored with targeting moieties were successfully employed to target tumors in living mice after tail intravenous injection. Expand
Caged siRNAs with Single cRGD Modification for Photoregulation of Exogenous and Endogenous Gene Expression in Cells and Mice.
TLDR
This study designed and synthesized a series of caged siRNAs through bioconjugation of cyclo(Arg-Gly-Asp-d-Phe-Lys) (cRGD) peptide to the 5' end of siRNA through a photolabile linker that enabled photochemical activation of si RNA activity and photomodulation of target gene expression using single cRGD cagedSiRNAs. Expand
Photomodulating Gene Expression by Using Caged siRNAs with Single‐Aptamer Modification
TLDR
It is expected that further optimized caged siRNAs featuring aptamer conjugation will be promising for practical applications to spatiotemporal photoregulation of gene expression in the future. Expand
Dextran-Conjugated Caged siRNA Nanoparticles for Photochemical Regulation of RNAi-Induced Gene Silencing in Cells and Mice.
TLDR
Caged siRNA nanoparticles with high serum stability not only show great promise for photoregulation of exogenous and endogenous gene expression for both in vitro and in vivo applications, but also provide a novel and convenient way to spatiotemporally control RNAi-induced gene silencing. Expand
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