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BACKGROUND Recent innovations in sequencing technologies have provided researchers with the ability to rapidly characterize the microbial content of an environmental or clinical sample with unprecedented resolution. These approaches are producing a wealth of information that is providing novel insights into the microbial ecology of the environment and human(More)
With ever increasing storage demands and management costs, object based storage is on the verge of becoming the next standard storage interface. The American National Standards Institute (ANSI) ratified the object based storage interface standard (also referred to as OSD T-10) in January 2005. In this paper we present our experiences building a reference(More)
Understanding the categorization of human diseases is critical for reliably identifying disease causal genes. Recently, genome-wide studies of abnormal chromosomal locations related to diseases have mapped >2000 phenotype-gene relations, which provide valuable information for classifying diseases and identifying candidate genes as drug targets. In this(More)
Extended Abstract 1. Introduction Provenance is a well-established concept in the art world where the lineage, pedigree or origins of a painting are critical to determining its authenticity and value. It is of equal importance in present and future data-rich environments ranging from computational biology, intelligence information gathering, to high energy(More)
With ever increasing storage demands and management costs, object based storage is on the verge of becoming the next standard storage interface. The American National Standards Institute (ANSI) ratified the object based storage interface standard (also referred to as OSD T-10) in January 2005. In this paper we present our experiences building a reference(More)
Malaria causes over one million deaths annually, posing an enormous health and economic burden in endemic regions. The completion of genome sequencing of the causative agents, a group of parasites in the genus Plasmodium, revealed potential drug and vaccine candidates. However, genomics-driven target discovery has been significantly hampered by our limited(More)
Recomputation of the previously evaluated similarity results between biological sequences becomes inevitable when researchers realize errors in their sequenced data or when the researchers have to compare nearly similar sequences, e.g., in a family of proteins. We present an efficient scheme for updating local sequence alignments with an affine gap model.(More)
According to the World Health organization, half the world's population is at risk of contracting malaria. They estimated that in 2010 there were 219 million cases of malaria, resulting in 660,000 deaths and an enormous economic burden on the countries where malaria is endemic. The adoption of various high-throughput genomics-based techniques by malaria(More)
DNA methylation has been linked to many important biological phenomena. Researchers have recently begun to sequence bisulfite treated DNA to determine its pattern of methylation. However, sequencing reads from bisulfite-converted DNA can vary significantly from the reference genome because of incomplete bisulfite conversion, genome variation, sequencing(More)