Changjie Zhang

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Anju Kelkar1
Sri R. Madabhushi1
1Anju Kelkar
1Sri R. Madabhushi
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BACKGROUND Von Willebrand Factor (VWF) A1-domain binding to platelet receptor GpIbα is an important fluid-shear dependent interaction that regulates both soluble VWF binding to platelets, and platelet tethering onto immobilized VWF. We evaluated the roles of different structural elements at the N-terminus of the A1-domain in regulating shear dependent(More)
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