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Melatonin inhibits adipogenesis and enhances osteogenesis of human mesenchymal stem cells by suppressing PPARγ expression and enhancing Runx2 expression
Abstract:  Adipogenesis and osteogenesis, a reciprocal relationship in bone marrow, are complex processes including proliferation of precursor cells, commitment to the specific lineage, and terminalExpand
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Sustained release of melatonin from poly (lactic‐co‐glycolic acid) (PLGA) microspheres to induce osteogenesis of human mesenchymal stem cells in vitro
Abstract:  Melatonin promotes bone formation and prevents bone degradation via receptor‐dependent or receptor‐independent actions. The aim of this study is to encapsulate melatonin into polyExpand
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Melatonin enhances chondrogenic differentiation of human mesenchymal stem cells
Intramembranous ossification and endochondral ossification are two ways through which bone formation and fracture healing occur. Accumulating amounts of evidence suggests that melatonin affectsExpand
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Aberrant activation of Hedgehog pathway in Nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is a very common head and neck cancer in southern china. Despite advances in surgical and chemotherapeutic approaches, its prognosis is still not promising. HedgehogExpand
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The effects of indigenous R&D activities on China's energy intensity: A regional perspective.
One of the most efficient and effective ways to cut energy intensity is through an increase in indigenous R&D activities. In the existing literature on the nexus of indigenous R&D and energyExpand
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Abnormal osteogenic and chondrogenic differentiation of human mesenchymal stem cells from patients with adolescent idiopathic scoliosis in response to melatonin
Abnormalities of membranous and endochondral ossification in patients with adolescent idiopathic scoliosis (AIS) remain incompletely understood. To investigate abnormalities in the melatoninExpand
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Systèmes et procédés consistant à utiliser un dispositif informatique comportant un noyau du système d'exploitation sécurisé
L'invention concerne un procede et un appareil permettant de resister a un code malveillant dans un dispositif informatique. Un composant de logiciel correspondant a un noyau du systemeExpand