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UNLABELLED We present a new rodent SPECT system (U-SPECT-II) that enables molecular imaging of murine organs down to resolutions of less than half a millimeter and high-resolution total-body imaging. METHODS The U-SPECT-II is based on a triangular stationary detector set-up, an XYZ stage that moves the animal during scanning, and interchangeable cylindric(More)
To maximize the time-integrated X-ray flux from multiple X-ray sources and shorten the data acquisition process, a promising way is to allow overlapped projections from multiple sources being simultaneously on without involving the source multiplexing technology. The most challenging task in this configuration is to perform image reconstruction effectively(More)
Experimental studies aimed at advancing understanding of human brain disease and malfunction, and of behavior problems, may be aided by computer models of small laboratory animals. ABSTRACT | With the steadily improving resolution of novel small-animal single photon emission computed tomography (SPECT) and positron emission tomography devices, highly(More)
Introduction. Spatially registering SPECT with CT makes it possible to anatomically localize SPECT tracers. In this study, an accurate method for the coregistration of ultra-high-resolution SPECT volumes and multiple cone-beam CT volumes is developed and validated, which does not require markers during animal scanning. Methods. Transferable animal beds were(More)
PURPOSE The finite Hilbert transform (FHT) or inverse finite Hilbert transform (IFHT) is recently found to have some important applications in computerized tomography (CT) arena, where they are used to filter the derivatives of back-projected data in the chord-line based CT reconstruction algorithms. In this paper, we implemented, improved and validated a(More)
PURPOSE In circular cone-beam microcomputed tomography (micro-CT), it is likely that the length of the Field of View (FOV) of a single acquisition is shorter than the total length of the object to be imaged, such as a rat in the case of preclinical application of micro-CT. This leads to multiple acquisitions using different bed positions with bed(More)
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