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Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways
TLDR
E elite inbred South African transgenic corn plants are created in which the levels of 3 vitamins were increased specifically in the endosperm through the simultaneous modification of 3 separate metabolic pathways, opening the way for the development of nutritionally complete cereals to benefit the world's poorest people. Expand
Combinatorial genetic transformation generates a library of metabolic phenotypes for the carotenoid pathway in maize
TLDR
This work recovered a diverse population of transgenic plants expressing different enzyme combinations and showing distinct metabolic phenotypes that allowed them to identify and complement rate-limiting steps in the pathway and to demonstrate competition between β-carotene hydroxylase and bacterial β- carotene ketolase for substrates in 4 sequential steps of the extended pathway. Expand
Transgenic strategies for the nutritional enhancement of plants.
TLDR
Current strategies for the biofortification of crops are reviewed, including mineral fertilization and conventional breeding but focusing on transgenic approaches which offer the most rapid way to develop high-nutrient commercial cultivars are reviewed. Expand
Light-dark regulation of carotenoid biosynthesis in pepper (Capsicum annuum) leaves.
TLDR
It could be demonstrated that light-independent degradation or conversion of carotenoids e.g. to abscisic acid is a minor process. Expand
Critical evaluation of strategies for mineral fortification of staple food crops
TLDR
A critical comparison of the strategies that have been developed to address deficiencies in five key mineral nutrients—iodine, iron, zinc, calcium and selenium is provided and the most recent advances in genetic engineering to increase mineral levels and bioavailability in the authors' most important staple food crops are discussed. Expand
Promoter diversity in multigene transformation
TLDR
Using illustrative case studies, this work discusses promoter deployment strategies in transgenic plants that increase the likelihood of successful and stable multiple transgene expression. Expand
A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health.
TLDR
This review, contributed by scientists of complementary disciplines related to carotenoid research, covers recent advances and provides a perspective on future directions on the subjects of carotENoid metabolism, biotechnology, and nutritional and health benefits. Expand
When more is better: multigene engineering in plants.
TLDR
Multigene transfer allows researchers to achieve goals that were once impossible - the import of entire metabolic pathways, the expression of entire protein complexes, the development of transgenic crops simultaneously engineered to produce a spectrum of added-value compounds. Expand
Patterns of CRISPR/Cas9 activity in plants, animals and microbes
TLDR
Critically analyse the activity of CRISPR/Cas9 and related systems in different plant species and compare the outcomes in animals and microbes to draw broad conclusions about the design principles required for effective genome editing in different organisms. Expand
The regulation of carotenoid pigmentation in flowers.
TLDR
Over the last decade, much has been learned about the impact of carotenoid metabolism on flower color development and the molecular basis of flower color, which means many of the natural colorful varieties the authors see around us can be explained and plants can be engineer to produce flowers with novel and exciting varieties that are not provided by nature. Expand
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