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Mitochondrial Dysfunction Promotes Breast Cancer Cell Migration and Invasion through HIF1α Accumulation via Increased Production of Reactive Oxygen Species
The results suggest that mitochondrial dysfunction promotes cancer cell motility partly through HIF1α accumulation mediated via increased production of reactive oxygen species and that ROS regulated malignant cellular behavior was in part mediated through upregulation of hypoxia-inducible factor-1 α and vascular endothelial growth factor.
Curcumin-Loaded Solid Lipid Nanoparticles Enhanced Anticancer Efficiency in Breast Cancer
The results suggested that Cur-SLNs could be a potential useful chemotherapeutic formulation for breast cancer therapy.
MiR-125b regulates epithelial-mesenchymal transition via targeting Sema4C in paclitaxel-resistant breast cancer cells
The role of miR-125b in regulation of EMT in stable paclitaxel-resistant (PR) breast cancer cells, namely MCF-7 PR and SKBR3 PR, and its role in governing its target Sema4C are explored are explored to suggest that up-regulation or targeting Sema 4C could serve as novel approaches to reverse chemotherapy resistance in breast cancers.
Anticancer Effects of Resveratrol-Loaded Solid Lipid Nanoparticles on Human Breast Cancer Cells
Results indicate that the resveratrol-loaded solid lipid nanoparticles (Res-SLN) may have great potential for breast cancer treatment.
The PDGF-D/miR-106a/Twist1 pathway orchestrates epithelial-mesenchymal transition in gemcitabine resistance hepatoma cells
Findings provide a possible molecular mechanism for understanding GR chemoresistance in HCC cells and suggest inactivation of PDGF-D/Twist or activation of miR-106a could be a novel strategy for the treatment of HCC.
Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway
The findings demonstrated that targeting PDGF-D could be a novel strategy to overcome gemcitabine resistance in HCC and down-regulation of PD GF-D in GR cells led to partial reversal of the EMT phenotype.
Arsenic trioxide suppresses transcription of hTERT through down-regulation of multiple transcription factors in HL-60 leukemia cells.
[Grape seed extract inhibit proliferation of breast cancer cell MCF-7 and decrease the gene expression of survivin].
- Chang-jie Chen, Chen-Wei Liu, J. Zhang, Qing-ling Yang, Fengmeng Teng
- BiologyZhongguo Zhong yao za zhi = Zhongguo zhongyao…
- 1 February 2009
GSE can inhibit the proliferation of breast cancer cell MCF-7 through arresting the cell cycle in S periods and the mechanism may be that GSE regulate the activity of transcription factor which are related to theActivity of core promoter of Survivin and decrease the gene expression of survivin.
Involvement of miR-451 in resistance to paclitaxel by regulating YWHAZ in breast cancer
It is shown that miR-451 is decreased in human breast cancer specimens and in paclitaxel-resistant (PR) cells, and the results of xenograft model in vivo showed that intratumor injection of miR -451 agomir induced a tumor-suppressive effect in SKBR3/PR drug-resistant xenografted model.
Lobaplatin arrests cell cycle progression in human hepatocellular carcinoma cells
- Qiong Wu, S. Qin, Feng-meng Teng, Chang-jie Chen, Rui Wang
- Biology, MedicineJournal of hematology & oncology
- 31 October 2010
Cytotoxicity of lobaplatin in human HCC cells might be due to its ability to arrest cell cycle progression which would contribute to the potential use of lob aplatin for the management of HCC.