Chang-bin Qiu

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OBJECTIVE To investigate the interrelation between endothelin-1 (ET-1) and angiotensin II (AngII) in kidney tissue of rats with diabetic nephropathy. METHODS Wistar rats were performed a removal operation of right kidney. Two weeks later the uninephrectomized rats were given intravenous injection of streptozotocin (STZ, 35 mg/kg). The diabetic rats were(More)
OBJECTIVE To investigate the therapeutic effects of endothelin receptor antagonist (bosentan) and angiotensin II type 1 receptor antagonist (valsartan) on renal interstitial fibrosis of rats with chronic aristolochic acid nephropathy (CAAN). METHODS A rat model of CAAN was established by gavage with extract of Aristolochia manshuriensis Kom(More)
OBJECTIVE To investigate the mechanism of COX-2's selective inhibitor, NS-398, on human colorectal adenoma development. METHODS The human colorectal adenoma cells were isolated and cultured identified. The cell growth rates were assessed, when treated with NS-398, by using MTT method. Expression of COX-2 protein in human colorectal tumor was examined by(More)
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