Chang Zhao

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Flora-2 is a rule-based object-oriented knowledge base system designed for a variety of automated tasks on the Semantic Web, ranging from meta-data management to information integration to intelligent agents. The Flora-2 system integrates F-logic, HiLog, and Transaction Logic into a coherent knowledge representation and inference language. The result is a(More)
Text segmentation is the process of converting information in unstructured text into structured records. This is an important problem since structured data is amenable to efficient query processing. CRFs are a class of discriminative probabilistic models that are gaining acceptance as an effective computing machinery for text segmentation. An important(More)
Osteoporosis (OP) often increases the risk of bone fracture and other complications and is a major clinical problem. Previous studies have found that high blood pressure is associated with bone formation abnormalities, resulting in increased calcium loss. We have investigated the effect of the antihypertensive drug benidipine on bone marrow stromal cell(More)
BACKGROUND Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5, also called as survivin) is a member of the inhibitor of apoptosis protein (IAP) family, which plays an important role in the occurrence and progression of cancer. Recently, a polymorphism in the promoter of BIRC5, -31C/G (rs9904341), was shown to influence BIRC5 expression. METHODS(More)
We studied the direct role of amyloid beta (Abeta) in regulating capacitive calcium entry (CCE), an important refilling mechanism for depleted intracellular calcium stores. For the first time, we found that Abeta can potentiate CCE. Neural 2a cells stably expressing Swedish mutant APP (APPswe), which can secrete large amounts of Abeta, have stronger CCE(More)
Profile Hidden Markov Models (PHMMs) are recognized as powerful computational vehicles for homology search of protein sequences. Extant PHMM training approaches either use completely unaligned or aligned sequences. The PHMMs resulting from these two training approaches present contrasting tradeoffs w.r.t. alignment information and the accuracy of the search(More)
The aim of the current study was to investigate the molecular mechanisms underlying hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) using the expression profiles of HCV-infected Huh7 cells at different time points. The differentially expressed genes (DEGs) were identified with the Samr package in R software once the data were normalized.(More)
Active sites in proteins are three dimensional substruc-tures that cause them to perform their function. The problem of finding substructures in a protein that are " similar " to the active sites of another protein has several important applications in biological sciences such as drug design, genetic engineering, and diagnostic tools for analysis of(More)
BACKGROUND The purpose of this study was to measure the tibiofemoral kinematics of anterior cruciate ligament (ACL) deficiency in a Chinese population and compare the kinematics with published data about a Caucasian population. METHODS Unilateral knees of 18 Chinese ACL-deficient (ACL-D) subjects were studied while subjects ascended stairs. Kinematic(More)
A1 Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling of propagating waves in visual cortex Alain Destexhe A3 Dynamics and biomarkers of mental disorders Mitsuo Kawato F1 Precise recruitment of spiking output at theta frequencies requires dendritic h-channels in multi-compartment models of(More)