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- Influence
Nickel (II)-induced cytotoxicity and apoptosis in human proximal tubule cells through a ROS- and mitochondria-mediated pathway.
- Yi-Fen Wang, Huey-Wen Shyu, +6 authors Chang-Yu Chen
- Biology, Medicine
- Toxicology and applied pharmacology
- 1 March 2012
Nickel compounds are known to be toxic and carcinogenic in kidney and lung. In this present study, we investigated the roles of reactive oxygen species (ROS) and mitochondria in nickel (II)… Expand
Nickel induces oxidative stress and genotoxicity in human lymphocytes.
- Chang-Yu Chen, Yi-Fen Wang, Wan-Ru Huang, Yu-Tyng Huang
- Chemistry, Medicine
- Toxicology and applied pharmacology
- 15 June 2003
In order to elucidate the oxidative effects and genotoxicity of nickel on human lymphocytes in vitro, we report the level of intracellular reactive oxygen species (ROS), lipid peroxidation, hydroxyl… Expand
Involvement of oxidative stress and caspase activation in paclitaxel-induced apoptosis of primary effusion lymphoma cells
- Yi-Fen Wang, Chang-Yu Chen, Su-Fang Chung, Yee-Hsuan Chiou, Horng-Ren Lo
- Biology, Medicine
- Cancer Chemotherapy and Pharmacology
- 12 June 2004
Paclitaxel has significant antitumor activity in several human tumors, including Kaposi’s sarcoma (KS). Human herpesvirus 8 (HHV-8) is implicated in all forms of Kaposi’s sarcoma, primary effusion… Expand
Effects of vitamin A pretreatment on nickel-induced lipid peroxidation and concentration of essential metals in liver, kidney and lung of mice
- Chang-Yu Chen, Y. Huang, Te-Hsien Lin
- Medicine, Chemistry
- Archives of Toxicology
- 1 May 1998
Abstract In the present study we report the effects of pretreatment with large doses of vitamin A (Vit A, retinol) on hepatic, renal and pulmonary lipid peroxidation, and Ni and essential metal (Fe,… Expand
Sodium butyrate induces apoptosis and cell cycle arrest in primary effusion lymphoma cells independently of oxidative stress and p21CIP1/WAF1 induction
- Yi-Fen Wang, Neou-Shi Chen, Yu-Ping Chung, L. Chang, Yee-Hsuan Chiou, Chang-Yu Chen
- Biology, Medicine
- Molecular and Cellular Biochemistry
- 14 February 2006
Primary effusion lymphoma, a peculiar type of B cell non-Hodgkin lymphoma, preferentially develops in immunodeficient individuals and its pathogenesis is closely linked with human herpesvirus 8… Expand
Nickel-induced oxidative stress and effect of antioxidants in human lymphocytes
- Chang-Yu Chen, Y. Wang, Yu-Hwan Lin, Shu-Fang Yen
- Chemistry, Medicine
- Archives of Toxicology
- 25 January 2003
The purpose of this study was to evaluate the oxidative effect in human lymphocytes after acute nickel (Ni) treatment for 1 h; levels of intracellular reactive oxygen species (ROS), lipid… Expand
Epigallocatechin-3-Gallate Suppresses Human Herpesvirus 8 Replication and Induces ROS Leading to Apoptosis and Autophagy in Primary Effusion Lymphoma Cells
- Ching-Yi Tsai, Chang-Yu Chen, +5 authors Yi-Fen Wang
- Chemistry, Medicine
- International journal of molecular sciences
- 21 December 2017
Epigallocatechin-3-gallate (EGCG), the major constituent of green tea, has been shown to induce cell death in cancer cells. Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by human… Expand
Nifedipine Modulates Renal Lipogenesis via the AMPK-SREBP Transcriptional Pathway
- Y. Lin, Mai-Szu Wu, +6 authors Chiung-Chi Peng
- Chemistry, Medicine
- International journal of molecular sciences
- 29 March 2019
Lipid accumulation in renal cells has been implicated in the pathogenesis of obesity-related kidney disease, and lipotoxicity in the kidney can be a surrogate marker for renal failure or renal… Expand
Resveratrol induces cell death and inhibits human herpesvirus 8 replication in primary effusion lymphoma cells.
- Feng-Yi Tang, Chang-Yu Chen, +7 authors Yi-Fen Wang
- Biology, Medicine
- Chemico-biological interactions
- 5 December 2015
Resveratrol (3,4',5-trihydroxy-trans-stilbene) has been reported to inhibit proliferation of various cancer cells. However, the effects of resveratrol on the human herpesvirus 8 (HHV8) harboring… Expand
NICKEL-INDUCED PLASMA LIPID PEROXIDATION AND EFFECT OF ANTIOXIDANTS IN HUMAN BLOOD: INVOLVEMENT HYDROXYL RADICAL FORMATION AND DEPLETION OF α-TOCOPHEROL
- Chang-Yu Chen, Yuh-Juan Su, Pey-Fen Wu, Mei-Miin Shyu
- Chemistry, Medicine
- Journal of toxicology and environmental health…
- 28 June 2002
To provide evidence for the oxidative effect of nickel (Ni) treatment on blood, lipid peroxidation (LPO) and hydroxyl radical ( ” OH) generation were examined in human plasma. Nickel chloride induced… Expand