Chang-Yu Chen

Publications26
h-index11
Citations434
Highly Influential Citations19
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Nickel (II)-induced cytotoxicity and apoptosis in human proximal tubule cells through a ROS- and mitochondria-mediated pathway.
Nickel compounds are known to be toxic and carcinogenic in kidney and lung. In this present study, we investigated the roles of reactive oxygen species (ROS) and mitochondria in nickel (II)… Expand
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Nickel induces oxidative stress and genotoxicity in human lymphocytes.
In order to elucidate the oxidative effects and genotoxicity of nickel on human lymphocytes in vitro, we report the level of intracellular reactive oxygen species (ROS), lipid peroxidation, hydroxyl… Expand
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Involvement of oxidative stress and caspase activation in paclitaxel-induced apoptosis of primary effusion lymphoma cells
Paclitaxel has significant antitumor activity in several human tumors, including Kaposi’s sarcoma (KS). Human herpesvirus 8 (HHV-8) is implicated in all forms of Kaposi’s sarcoma, primary effusion… Expand
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Effects of vitamin A pretreatment on nickel-induced lipid peroxidation and concentration of essential metals in liver, kidney and lung of mice
Abstract In the present study we report the effects of pretreatment with large doses of vitamin A (Vit A, retinol) on hepatic, renal and pulmonary lipid peroxidation, and Ni and essential metal (Fe,… Expand
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Sodium butyrate induces apoptosis and cell cycle arrest in primary effusion lymphoma cells independently of oxidative stress and p21CIP1/WAF1 induction
Primary effusion lymphoma, a peculiar type of B cell non-Hodgkin lymphoma, preferentially develops in immunodeficient individuals and its pathogenesis is closely linked with human herpesvirus 8… Expand
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Nickel-induced oxidative stress and effect of antioxidants in human lymphocytes
The purpose of this study was to evaluate the oxidative effect in human lymphocytes after acute nickel (Ni) treatment for 1 h; levels of intracellular reactive oxygen species (ROS), lipid… Expand
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Epigallocatechin-3-Gallate Suppresses Human Herpesvirus 8 Replication and Induces ROS Leading to Apoptosis and Autophagy in Primary Effusion Lymphoma Cells
Epigallocatechin-3-gallate (EGCG), the major constituent of green tea, has been shown to induce cell death in cancer cells. Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by human… Expand
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Nifedipine Modulates Renal Lipogenesis via the AMPK-SREBP Transcriptional Pathway
Lipid accumulation in renal cells has been implicated in the pathogenesis of obesity-related kidney disease, and lipotoxicity in the kidney can be a surrogate marker for renal failure or renal… Expand
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Resveratrol induces cell death and inhibits human herpesvirus 8 replication in primary effusion lymphoma cells.
Resveratrol (3,4',5-trihydroxy-trans-stilbene) has been reported to inhibit proliferation of various cancer cells. However, the effects of resveratrol on the human herpesvirus 8 (HHV8) harboring… Expand
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NICKEL-INDUCED PLASMA LIPID PEROXIDATION AND EFFECT OF ANTIOXIDANTS IN HUMAN BLOOD: INVOLVEMENT HYDROXYL RADICAL FORMATION AND DEPLETION OF α-TOCOPHEROL
To provide evidence for the oxidative effect of nickel (Ni) treatment on blood, lipid peroxidation (LPO) and hydroxyl radical ( ” OH) generation were examined in human plasma. Nickel chloride induced… Expand
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