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Relation of serum potassium level to long-term outcomes in patients with acute myocardial infarction.
TLDR
There is a need for change in current concepts of the ideal serum potassium levels in patients with AMI, as the long-term mortality was lowest in the group of patients with potassium levels of 3.5 to <4.0 mEq/L, whereas mortality was higher in the patients withassium levels≥4.5 or <3.5 mEQ/L. Expand
Renoprotective effects of the direct renin inhibitor aliskiren on gentamicin-induced nephrotoxicity in rats
  • E. Bae, I. Kim, +6 authors S. Kim
  • Chemistry, Medicine
  • Journal of the renin-angiotensin-aldosterone…
  • 1 December 2014
TLDR
Aliskiren attenuates gentamicin-induced nephropathy by suppression of inflammatory, profibrotic and apoptotic factors through inhibition of the nuclear factor κB, Smads and mitogen-activated protein kinase signaling pathways. Expand
Incidence, Predictive Factors, and Clinical Outcomes of Acute Kidney Injury after Gastric Surgery for Gastric Cancer
TLDR
A retrospective study of patients with normal renal function who underwent partial or total gastrectomy for gastric cancer between June 2002 and December 2011 identified several factors associated with postoperative AKI; recognition of these predictive factors may help reduce the incidence of AKI. Expand
Acute Kidney Injury in Patients with Sepsis and Septic Shock: Risk Factors and Clinical Outcomes
TLDR
Investigation of clinical characteristics and risk factors of acute kidney injury (AKI) in patients with sepsis and septic shock revealed that development of septic AKI was associated with poor clinical outcomes, and the severity of AKIwas associated with increased mortality. Expand
GFR and cardiovascular outcomes after acute myocardial infarction: results from the Korea Acute Myocardial Infarction Registry.
TLDR
eGFR was associated independently with mortality and complications after AMI, and use of β-blockers, angiotensin-converting enzyme (ACE) inhibitors or angiotENSin receptor blockers (ARBs), and statins was associated with decreased risk of MACEs. Expand
Impact of partial nephrectomy on kidney function in patients with renal cell carcinoma
TLDR
Compared to PN, RN for even a moderate sized RCC leads to an increased incidence of AKI and new-onset CKD, and is a significant risk factor for kidney function decline, therefore, PN should be considered as the choice of surgical treatment for RCCs that are ≤7 cm in diameter in order to preserve renal function postoperatively. Expand
Nicotine-Induced Apoptosis in Human Renal Proximal Tubular Epithelial Cells
TLDR
Nicotine caused apoptosis in HK-2 cells by inducing ROS generation that activated the NF-κB signaling pathway via the MAPK pathway and it arrested the cell cycle at the G2/M phase. Expand
Association of Pulse Wave Velocity and Pulse Pressure With Decline in Kidney Function
TLDR
PP is an independent risk factor for rapid decline in kidney function in populations with relatively preserved kidney function (estimated GFR ≥30 mL/min/1.73 m2) and Arterial stiffness assessed using cfPWV and baPWVs was not correlated with lower estimated GFR and rapid declineIn kidney function after adjustment for various confounders. Expand
Hyperuricemia has increased the risk of progression of chronic kidney disease: propensity score matching analysis from the KNOW-CKD study
TLDR
Hyperuricemia appears to be an independent risk factor for composite renal outcome, but allopurinol and febuxostat did not show reno-protective effect. Expand
Pharmacologic Management of the Cardio-renal Syndrome
TLDR
Modern therapies, including phosphodiesterase inhibitors, vasopressin antagonists, adenosine A1 receptor antagonists, and renal protective dopamine have shown encouraging results in some patients with heart failure, but have failed to demonstrate a clear superiority over more conventional treatments. Expand
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