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Curcumin Inhibits Immunostimulatory Function of Dendritic Cells: MAPKs and Translocation of NF-κB as Potential Targets1
Curcumin has been shown to exhibit anti-inflammatory, antimutagenic, and anticarcinogenic activities. However, the effect of curcumin on the maturation and immunostimulatory function of dendriticExpand
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Blockade of Indoleamine 2,3-Dioxygenase Protects Mice against Lipopolysaccharide-Induced Endotoxin Shock1
Suppression of an excessive systemic inflammatory response is a promising and potent strategy for treating endotoxic sepsis. Indoleamine 2,3-dioxygenase (IDO), which is the rate-limiting enzyme forExpand
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Admissions to intensive care unit of HIV-infected patients in the era of highly active antiretroviral therapy: etiology and prognostic factors
IntroductionAlthough access to highly active antiretroviral therapy (HAART) has prolonged survival and improved life quality, HIV-infected patients with severe immunosuppression or comorbidities mayExpand
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Differential regulation of indoleamine 2,3‐dioxygenase by lipopolysaccharide and interferon gamma in murine bone marrow derived dendritic cells
Indoleamine 2,3‐dioxygenase (IDO) is a rate‐limiting enzyme in the l‐tryptophan‐kynurenine pathway, which converts an essential amino acid, l‐tryptophan, to N‐formylkynurenine. The expression of IDOExpand
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Proteoglycan isolated from Phellinus linteus induces toll-like receptors 2- and 4-mediated maturation of murine dendritic cells via activation of ERK, p38, and NF-kappaB.
Mushroom polysaccharides are increasingly being utilized to treat a wide variety of diseases. Phellinus linteus proteoglycan (PL) has been reported to have anti-tumor and immunomodulatory properties.Expand
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Quercetin regulates Th1/Th2 balance in a murine model of asthma.
Quercetin is found to be the most active of the flavonoids in studies and many medicinal plants owe much of their activity to their high Quercetin content. Quercetin has demonstrated significantExpand
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Curcumin Suppresses the Induction of Indoleamine 2,3-Dioxygenase by Blocking the Janus-activated Kinase-Protein Kinase Cδ-STAT1 Signaling Pathway in Interferon-γ-stimulated Murine Dendritic Cells*
Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial and rate-limiting step in the degradation of tryptophan and is strongly induced in interferon-γ (IFNγ)-stimulated dendritic cells (DCs). IDOExpand
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IL-18 induces emphysema and airway and vascular remodeling via IFN-γ, IL-17A, and IL-13.
RATIONALE Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation, alveolar destruction, and airway and vascular remodeling. However, the mechanisms that lead to theseExpand
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Cilostazol is anti‐inflammatory in BV2 microglial cells by inactivating nuclear factor‐kappaB and inhibiting mitogen‐activated protein kinases
Background and purpose:  Cilostazol is a specific inhibitor of 3′‐5′‐cyclic adenosine monophosphate (cAMP) phosphodiesterase, which is widely used to treat ischemic symptoms of peripheral vascularExpand
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Amphiregulin, an Epidermal Growth Factor Receptor Ligand, Plays an Essential Role in the Pathogenesis of Transforming Growth Factor-β-induced Pulmonary Fibrosis
  • Y. Zhou, J. Lee, +8 authors C. Lee
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 19 October 2012
Background: The interaction between TGF-β and EGFR signaling in the pathogenesis of pulmonary fibrosis has not been defined. Results: Amphiregulin (AR), a EGFR ligand, is induced by TGF-β stimulationExpand
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