Share This Author
Manzamine Alkaloids from an Acanthostrongylophora sp. Sponge.
The structure of kepulauamine A was determined to possess an unprecedented pyrrolizine moiety, while others were functional group variants of known manzamines.
Gombamide A, a cyclic thiopeptide from the sponge Clathria gombawuiensis.
The new peptide, gombamide A, was isolated from the marine sponge Clathria gombawuiensis and exhibited weak cytotoxicity against A549 and K562 cell lines as well as moderate inhibitory activity against Na(+)/K(+)-ATPase.
Meroterpenoids from a Tropical Dysidea sp. Sponge.
Six new meroterpenoids (1-6), along with arenarol (7), a known rearranged drimane sesquiterpene hydroquinone, were isolated from a Dysidea sp. sponge collected from the Federated States of…
Gombaspiroketals A-C, sesterterpenes from the sponge Clathria gombawuiensis.
Gombaspiroketals A-C (1-3), tetracyclic sesterterpenes of a novel skeletal class, were isolated from the Korean marine sponge Clathria gombawuiensis and exhibited moderate cytotoxicities and antibacterial activities.
Suvanine sesterterpenes and deacyl irciniasulfonic acids from a tropical Coscinoderma sp. sponge.
The suvanines, a new suvanine salt, five new (2, 4-8) and two known sesterterpenes from the same structural class, and two new modified lipids (9 and 10) were isolated from a Coscinoderma sp. sponge…
Spatholobus suberectus Dunn. constituents inhibit sortase A and Staphylococcus aureus cell clumping to fibrinogen
- Hyunjoo Cho, B. Chung, Chang-Kwon Kim, D. Oh, K. Oh, Jongheon Shin
- Biology, ChemistryArchives of pharmacal research
- 18 January 2017
The suppression of cell-clumping activity indicates the potential of these compounds in the treatment of S. aureus infections via the inhibition of SrtA, a key transpeptidase for bacterial virulence.
Inhibitory Effects of Flavonoids from Spatholobus suberectus on Sortase A and Sortase A-Mediated Aggregation of Streptococcus mutans.
- Wanki Park, Chan-Hong Ahn, Hyunjoo Cho, Chang-Kwon Kim, Jongheon Shin, K. Oh
- ChemistryJournal of microbiology and biotechnology
- 28 August 2017
Among the flavonoids tested, 7-hydroxy-6-methoxyflavanone (1) and formononetin (4) exhibited strong inhibitory activity against Streptococcus mutans SrtA, but did not affect cell viability.
Additional sesterterpenes and a nortriterpene saponin from the sponge Clathria gombawuiensis.
- Jung-Kyun Woo, Chang-Kwon Kim, Chan-Hong Ahn, D. Oh, K. Oh, Jongheon Shin
- ChemistryJournal of natural products
- 29 January 2015
Three new terpene metabolites were isolated from the marine sponge Clathria gombawuiensis collected from Korean waters and exhibited moderate cytotoxicity against A549 and K562 cell lines, and compound 3 showed antibacterial activity.
Neopetrothiazide: An Intriguing Pentacyclic Thiazide Alkaloid from the Sponge Neopetrosia sp.
NMR pulse sequences optimized to detect four- and five-bond 1H-13C heteronuclear correlations can help assign proton-deficient structural motifs like neopetrothiazide (1), which has 14 contiguous nonprotonated centers.
Callyazepin and (3R)-Methylazacyclodecane, Nitrogenous Macrocycles from a Callyspongia sp. Sponge.
Callyazepin (1) and (3R)-methylazacyclodecane (2), nitrogenous macrocycles, were isolated from a tropical Callyspongia sp. sponge. The combined spectroscopic analyses revealed that the structure of 1…