Chang-Joon Lee

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In an effort to improve drug design and predictions for pharmacokinetics (PK), an empirical model was developed to predict the activation energies (Ea) of cytochrome P450 (CYP450) mediated metabolism. The model, EaMEAD (Activation energy of Metabolism reactions with Effective Atomic Descriptors), predicts the Ea of four major metabolic reactions of the(More)
The solvation free energy density (SFED) model was modified to extend its applicability and predictability. The parametrization process was performed with a large, diverse set of solvation free energies that included highly polar and ionic molecules. The mean absolute error for 1200 solvation free energies of the 379 neutral molecules in 9 organic solvents(More)
Currently carotid artery stenting (CAS) is a widely used technique for the treatment of carotid artery stenosis. However, some patients with restenosis following CAS have been reported, resulting in potential clinical problems. The purpose of this study was to investigate the hemodynamic changes before and after CAS to find the factors that may influence(More)
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