Chang-Hung Chen

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Transforming growth factor (TGF)-beta inhibits T cell proliferation and differentiation. TGF-beta has been shown to inhibit the expression of transcription factors such as GATA-3 and T-bet that play important roles in T cell differentiation. Here we show that TGF-beta inhibits T cell differentiation at a more proximal step. An early event during T cell(More)
PURPOSES The cognitive sequelae and influence of depression in patients with cryptococcal meningitis (CM) after complete anti-fungal treatment has not been completely surveyed in literature. METHODS Seventeen HIV-negative CM patients and 26 health y controls were enrolled in this prospective study. Neuro-psychological evaluation was performed to assess(More)
In this study, large-eddy simulations (LESs) were performed to investigate the effects of changing wind direction on the turbine wakes and associated power losses in the Horns Rev offshore wind farm. In the LES framework, the turbulent subgrid-scale stresses are parameterized using a tuning-free Lagrangian scale-dependent dynamic model, and the(More)
PURPOSE Use Taiwanese version of the Montreal Cognitive Assessment (MoCA) in evaluating patients in different stages of Alzheimer's disease (AD) and correlate with white matter change. METHODS Ninety-seven normal controls (NC), 52 very-mild AD (clinical dementia rating [CDR] = 0.5), 48 mild AD (CDR = 1) and 38 moderate AD (CDR = 2) patients were enrolled(More)
PURPOSE Pallidoreticular damage was defined by lesions involving both the pallidum and the substantia nigra and was only reported in four cases after CO intoxication. CASE REPORT We report a patient with initial consciousness disturbances followed by parkinsonian features after carbon monoxide intoxication. The unique features in this patient included(More)
A personal computer (PC) based platform for visual telephone prototyping is introduced in this paper. ITU-T H.324 standard is the basis of the whole system. Video compression algorithms are implemented to achieve satisfactory visual quality for bit-rate less than 28.8 Kbps. Window menu interactive environment and modem communication interface are developed.(More)
INTRODUCTION We describe an immunocompromised patient with Tsukamurella tyrosinosolvens bacteremia and coinfection of Mycobacterium bovis pneumonia. CASE DESCRIPTION A 75-year-old male was admitted to our hospital complaining of persistent fever with general malaise. His medical history showed that he had diabetes mellitus (HbA1C 9.2%). A chest computed(More)
BACKGROUND Although it has been established that antiphospholipid antibodies (APAbs) bind to and modulate the signaling of cerebellar neurons in vitro, the clinical correlation between increased APAbs and cerebellar ataxia has rarely been investigated. METHODS We reviewed 10 patients presenting with cerebellar ataxia with increased blood APAbs from our(More)
PURPOSE Silent brain infarctions (SBI) commonly go unnoticed due to the subtlety of their neurological signs. However, there is the risk of subsequent symptomatic stroke and dementia. A better understanding of the risk factors of SBI may help accurately predict those who will require treatment. METHODS This one-year retrospective study enrolled 199 adult(More)
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