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  • Ying Zhang, P. G. Talalay, Chang Gun Cho, Gary H. Posner
  • Biology, Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1992 (First Publication: 15 March 1992)
  • Consumption of vegetables, especially crucifers, reduces the risk of developing cancer. Although the mechanisms of this protection are unclear, feeding of vegetables induces enzymes of xenobioticContinue Reading
  • Ying Zhang, Thomas W Kensler, Chang Gun Cho, Gary H. Posner, P. G. Talalay
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1994 (First Publication: 12 April 1994)
  • Sulforaphane [1-isothiocyanato-4-(methyl-sulfinyl)butane] was recently isolated from one variety of broccoli as the major and very potent inducer of phase 2 detoxication enzymes in murine hepatomaContinue Reading
  • Karen Evans, Esther Berger, Chang Gun Cho, Karl H. Weisgraber, P. T. Jun. Lansbury
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1995 (First Publication: 31 January 1995)
  • The apolipoprotein E4 (APOE4) allele is associated with an early age of onset of the nonfamilial form of Alzheimer disease (AD) and with increased beta protein amyloid deposition in the brain. TheseContinue Reading
  • Gary H. Posner, Chang Gun Cho, J V Green, Yingru Zhang, P. G. Talalay
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 1994
  • Thirty-five bifunctional isothiocyanates were synthesized as structural analogs of sulforaphane [(-)-1-isothiocyanato-4(R)-(methylsulfinyl)butane] that was recently isolated from broccoli as theContinue Reading
  • Wanxin Zhen, Hyo-Kyung Han, Magdalena Anguiano, Cynthia A. Lemere, Chang Gun Cho, P. T. Jun. Lansbury
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 1999 (First Publication: 1 July 1999)
  • The definitive diagnosis of Alzheimer's disease (AD) requires the detection of amyloid plaques in postmortem brain. Although the amount of fibrillar amyloid roughly correlates with the severity ofContinue Reading