Chang-Gui Gu

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The phase-splitting behavior of coupled suprachiasmatic-nucleus neurons has been observed in many mammals, and its mechanism is still not completely understood. Based on our previous work [C. Gu, J. Wang, and Z. Liu, Phys. Rev. E 80, 030904(R) (2009)] on the free-running periods of neurons in the suprachiasmatic nucleus, we present here a modified Goodwin(More)
The suprachiasmatic nucleus (SCN) pacemaker shows a free-running period ranging from 20 to 28 h for different species, which was usually explained from the angle of coupling strength. Based on the assumption of nonidentical coupling strengths in SCN, we find an alternative mechanism that the diversity of free-running period can be also caused by the(More)
In healthy humans and other animals, behavioral activity exhibits scale invariance over multiple timescales from minutes to 24 h, whereas in aging or diseased conditions, scale invariance is usually reduced significantly. Accordingly, scale invariance can be a potential marker for health. Given compelling indications that exercise is beneficial for mental(More)
In mammals, the central clock in the suprachiasmatic nucleus (SCN) controls physiological and behavioral circadian rhythms and is entrained to the external light-dark cycle. The ability of the SCN to entrain can be measured by exposing the animal to a light-dark cycle with a duration that deviates from 24 h (T-cycles); a wider entrainment range reflects a(More)
The synchronization of biological activity with the alternation of day and night (circadian rhythm) is performed in the brain by a group of neurons, constituting the suprachiasmatic nucleus (SCN). The SCN is divided into two subgroups of oscillating cells: the ventrolateral (VL) neurons, which are exposed to light (photic signal), and the dorsomedial (DM)(More)
Network based time series analysis has made considerable achievements in the recent years. By mapping mono/multivariate time series into networks, one can investigate both it's microscopic and macroscopic behaviors. However, most proposed approaches lead to the construction of static networks consequently providing limited information on evolutionary(More)
The suprachiasmatic nucleus (SCN) is the master circadian clock in mammals and is composed of thousands of neuronal oscillators expressing different intrinsic periods. These oscillators form a coupled network with a free-running period around 24 h in constant darkness and entrainable to the external light-dark cycle (T cycle). Coupling plays an important(More)
The principle clock of mammals, named suprachiasmatic nucleus (SCN), coordinates the circadian rhythms of behavioral and physiological activity to the external 24 h light-dark cycle. In the absence of the daily cycle, the SCN acts as an endogenous clock that regulates the ~24 h rhythm of activity. Experimental and theoretical studies usually take the(More)
The main clock located in the suprachiasmatic nucleus (SCN) regulates circadian rhythms in mammals. The SCN is composed of approximately twenty thousand heterogeneous self-oscillating neurons, that have intrinsic periods varying from 22 h to 28 h. They are coupled through neurotransmitters and neuropeptides to form a network and output a uniform periodic(More)
The suprachiasmatic nucleus (SCN) adapts to both the external light-dark (LD) cycle and seasonal changes in day length. In short photoperiods, single-cell activity patterns are tightly synchronized (i.e., in phase); in long photoperiods, these patterns are relatively dispersed, causing lower amplitude rhythms. The limit cycle oscillator has been used to(More)