Chang-Chieng Soon

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BACKGROUND Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer, with unclear histogenesis. To date there is no consensus on the optimal treatment of this neoplasm, with controversy surrounding the use of radiotherapy and chemotherapy. There are also limited data on biological behaviour and prognosis, with reported survival ranging from 31% at(More)
BACKGROUND Metabolic factors associated with coronary atherosclerosis (CA) in metabolic syndrome (MetS) remain unclear. METHODS A total of 550 consecutive subjects without documented coronary artery disease who received contrast-enhanced coronary computed tomography angiography were analyzed. CA was defined as coronary artery calcification (CAC) scores >0(More)
8528 Background: Axitinib is a potent inhibitor of VEGFR, PDGFR, and c-Kit with impressive single agent activity in advanced melanoma. We tested the hypothesis that axitinib may increase the effectiveness of carboplatin and paclitaxel in advanced melanoma, and we evaluated tumor genotype as a biomarker for response. METHODS We conducted a prospective(More)
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