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Synthesis, structure-activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents.
TLDR
Interestingly, compound 4e could inhibit not only HBsAg and HBeAg secretions but also HBV DNA replication with SI values of 20.3, 125.0 and 104.9.
UFLC/MS-IT-TOF guided isolation of anti-HBV active chlorogenic acid analogues from Artemisia capillaris as a traditional Chinese herb for the treatment of hepatitis.
TLDR
The results of this investigation support the ethnopharmacological use of Artemisia capillaris as anti-HBV agents and show that carboxyl group is closely associated to the anti- HBV activity.
Swerilactones A and B, anti-HBV new lactones from a tradtional Chinese herb: Swertia mileensis as a treatment for viral hepatitis.
TLDR
In vitro antihepatitis B virus (HBV) assay on Hep G 2.2.15 cell line showed that compound 1 inhibited HBsAg and HBeAg secretion with IC(50) values of 3.66 and 3.58 mM, respectively.
Two New Lignans and Anti‐HBV Constituents from Illicium henryi
TLDR
Two new lignans, dihydrodehydrodiconiferyl alcohol and threo‐4,9,9′‐trihydroxy‐3,3′‐dimethoxy‐8‐O‐4′‐neolignan 7‐O-α‐rhamnopyranoside, were isolated from Illicium henryi, together with ten known compounds, 3–12, and their structures were elucidated by extensive spectroscopic analyses.
Anti-hepatitis B virus active constituents from Swertia chirayita.
TLDR
Four new compounds swertiachiralatone A, swerto-4'-O-β-d-glucopyranoside, together with twenty-six known ones were isolated from the ethanol extract of Swertia chirayita, and their structures were elucidated by extensive spectroscopic analyses.
Polyacetylenes and anti-hepatitis B virus active constituents from Artemisia capillaris.
TLDR
Twenty-five compounds possessed inhibitory activity against HBV DNA replication according to the anti-HBV assay on HepG 2.15 cell line in vitro and the most active compound 12 could inhibit not only the secretions of HBsAg and HBeAg, but also HBVDNA replication.
Bioactivity-guided isolation of anti-hepatitis B virus active sesquiterpenoids from the traditional Chinese medicine: Rhizomes of Cyperus rotundus.
ETHNOPHARMACOLOGICAL RELEVANCE The rhizome of Cyperus rotundus (C. rotundus) is a well-known traditional Chinese medicine to cure hepatitis in many formulae, but the active components responsible for
Two new phenylpropanoid derivatives and other constituents from Illicium simonsii active against oral microbial organisms.
Bioassay-guided fractionation of the ethanol extract of the leaves and stems of Illicium simonsii led to the isolation of two new compounds, simonin A (1) and 1-hydroxyl-2- O- β-
Mulberrofuran G and isomulberrofuran G from Morus alba L.: anti-hepatitis B virus activity and mass spectrometric fragmentation.
TLDR
Mulberrofuran G showed moderate activity, inhibiting hepatitis B virus (HBV) DNA replication with the IC(50) value of 3.99 μM, according to the anti-HBV assay on the HepG 2.2.15 cell line in vitro.
Swerilactones C and D, anti-HBV new lactones from a traditional Chinese herb: Swertia mileensis.
TLDR
In vitro antihepatitis B virus (HBV) assay on the Hep G 2.2.15 cell line showed that both compounds 1 and 2 exhibited inhibitory activities against the secretion of HBsAg and HBeAg.
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