Chandrasekara G. Reddy

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The present study was undertaken to assess and compare the toxic effects of papaverine hydrochloride and its metabolites. Primary cell cultures of rat hepatocytes were treated with papavarine (papaver), 3′-O-desmethyl (3′-OH), 4′-O-desmethyl (4′-OH), and 6-O-desmethyl (6-OH) papaverine at 1×10−5, 1×10−4, and 1×10−3 M for 4,8, 12, and 24-h periods. Cell(More)
A simple and rapid reverse-phase high-performance liquid chromatographic (RP-HPLC) method was developed and validated for the simultaneous separation and estimation of gefitinib (an anti-cancer drug) and its process-related impurities. Five process-related impurities of gefitinib were separated on an Inertsil ODS-3V column (250 × 4.6 mm i.d.; particle size(More)
In the present work Al20Mg2Si2Cu alloy was synthesized by spray deposition technique followed by hot pressed, heat treated and dry sliding wear behavior of double aged Al20Mg2Si2Cu alloy was investigated. The alloy was solution treated in single step (1 hr at 480 o C) single aged (3 hrs at 210 o C ) and the alloy sample was solution treated in two step (1(More)
A simple and rapid reverse-phase high-performance liquid chromatographic (HPLC) method for the simultaneous separation and determination of erlotinib and its process-related impurities in bulk drugs has been developed. Five process-related impurities of erlotinib have been separated on an Inerstsil ODS-3V (C18) column and detected at 254 nm using a photo(More)
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