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- Chandrasekar Durairaj, Rajendra S. Kadam, John William Chandler, Stephen L Hutcherson, Uday B. Kompella
- Investigative ophthalmology & visual science
- 2010
PURPOSE
Dendrimeric polyguanidilyated translocators (DPTs) are nanosized novel dendrimers that efficiently translocate molecules across biological barriers. The purpose of this study was to develop a… (More)
- Sneha M Sundaram, Chandrasekar Durairaj, Rajendra S. Kadam, Uday B. Kompella
- Molecular cancer therapeutics
- 2009
Docetaxel, a chemotherapeutic agent currently used for improving survival of prostate cancer patients, suffers from low therapeutic index. The objective of this study was to prepare a new docetaxel… (More)
- Esther Kim, Chandrasekar Durairaj, +5 authors Henry F. Francis Edelhauser
- Pharmaceutical Research
- 2009
To determine the transscleral permeability of chemotherapeutic drugs vinblastine and doxorubicin for treatment of intraocular tumors, and to compare the use of doxorubicin encapsulated in PLGA and… (More)
- Shin Jeong Kang, Chandrasekar Durairaj, Uday B. Kompella, Joan M. O'Brien, Hans E. Grossniklaus
- Archives of ophthalmology
- 2009
OBJECTIVE
To evaluate the efficacy of subconjunctival nanoparticle carboplatin in the treatment of transgenic murine retinoblastoma.
METHODS
Dendrimeric nanoparticles loaded with carboplatin were… (More)
- Chandrasekar Durairaj, Jaymin C. Shah, Shruti Senapati, Uday B. Kompella
- Pharmaceutical Research
- 2008
The aim of this study was to develop quantitative structure pharmacokinetic relationships (QSPKR) to correlate drug physicochemical properties (molecular weight, lipophilicity, and drug solubility),… (More)
- Carolyn K. Pan, Chandrasekar Durairaj, +5 authors Jeffrey L. Olson
- Journal of ocular pharmacology and therapeutics…
- 2011
OBJECTIVE
The objective of this study was to compare the reduction in size of experimentally induced choroidal neovascularization (CNV) in rat eyes treated with bevacizumab, poly(ethylene-glycol)… (More)
- Chandrasekar Durairaj, James E Chastain, Uday B. Kompella
- Experimental eye research
- 2012
The purpose of this study was to quantify the melanin pigment content in sclera, choroid-RPE, and retina, three tissues encountered during transscleral drug delivery to the vitreous, in human,… (More)
- Sneha M Sundaram, Ruchit Trivedi, Chandrasekar Durairaj, Rajagopal Ramesh, Balamurali Krishna Ambati, Uday B. Kompella
- Clinical cancer research : an official journal of…
- 2009
PURPOSE
To evaluate the efficacy of a novel docetaxel derivative of deslorelin, a luteinizing hormone-releasing hormone (LHRH) agonist, and its combination in vivo with RGD peptide conjugated… (More)
- Chandrasekar Durairaj, Jie Shen, Madhu Cherukury
- Pharmaceutical Research
- 2014
To develop a mechanism based translational pharmacokinetic-pharmacodynamic (PKPD) model in preclinical species and to predict the intraocular pressure (IOP) following drug treatment in patients with… (More)
METHODS. Diclofenac acid was prepared and characterized in a suspension formulation. Rabbit eyes were injected with either diclofenac sodium solution (0.3 mg) or diclofenac acid suspension (10 mg)… (More)