Chandran Govindasamy

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Nitric oxide (NO) is involved in many pathophysiological processes in the brain. NO is synthesized from arginine by nitric oxide synthase (NOS) enzymes. Citrulline formed as a by-product of the NOS reaction, can be recycled to arginine by successive actions of argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) via the citrulline-NO cycle.(More)
  • C Govindasamy, Arulpriya M, Ruban P, Francisca Jenifer, Ilayaraja A
  • 2011
Seagrasses are considered as good indicators of heavy metals in the marine environment. Palk Strait is situated in the southeast coast of India, dominated with the seagrasses. The aim of this investigation to measure the various metals concentration (Mn, Fe, Cu and Zn) in two seagrasses species, Cymodocea serrulata, Syringodium isoetifolium in four selected(More)
Hypertension is a risk factor for several cardiovascular diseases and oxidative stress suggested to be involved in the pathophysiology. Antihypertensive drug Clonidine action in ameliorating oxidative stress was not well studied. Therefore, this study investigate the effect of Clonidine on oxidative stress markers and nitric oxide (NO) in SHR and nitric(More)
The aim of this study was to determine the immunoreactivity of neuronal and inducible nitric oxide synthetase, argininosuccinate synthetase, argininosuccinate lyase, glutamine synthetase in different regions of brain in rats of kainic acid mediated epilepsy. Male Sprague-Dawley rats were used in this study. The acute group animals were sacrificed after 2(More)
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