Chandrabhan Seniya

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Mammalian gastric lipases are stable and active under acidic conditions and also in the duodenal lumen. There has been considerable interest in acid stable lipases owing to their potential application in the treatment of pancreatic exocrine insufficiency. In order to gain insights into the domain movements of these enzymes, molecular dynamics simulations of(More)
The study of Human immunodeficiency virus (HIV) in humans and animal models in last 31 years suggested that it is a causative agent of AIDS. This causes serious pandemic public health concern globally. It was reported that the HIV-1 reverse transcriptase (RT) played a critical role in the life cycle of HIV. Therefore, inhibition of HIV-1RT enzyme is one of(More)
Survivin plays a crucial role in cell division particularly during the development of the fetus, in the onset and progression of most tumors and is found expressed in a few terminally differentiated cells. Altogether, there are ten splice variants of survivin, some of which are not yet satisfactorily characterized. Several isoforms may undergo(More)
The leaves extract of Calotropis gigantea were screened for its antibacterial and phytochemical activities. The solvents used for the leaves extraction were n-Hexane, Ethanol, Methanol, Chloroform, Water and Ethyl acetate. The extract was tested against Bacillus cereus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus,(More)
4-hydroxypanduratin A is a secondary metabolite of Boesenbergia pandurata Schult. (Fingerroot) plant with various pharmacological activities such as neuroprotective, potent antioxidant, antibacterial and antifungal. Flaviviral NS2B/NS3 protease activity is essential for polyprotein processing and viral replication for Japanese Encephalitis Virus (JEV), a(More)
Cholinesterase inhibitors (ChE-Is) are the standard for the therapy of AD associated disorders and are the only class of approved drugs by the Food and Drug Administration (FDA). Additionally, acetylcholinesterase (AChE) is the target for many Alzheimer's dementia drugs which block the function of AChE but have some side effects. Therefore, in this paper,(More)
In this paper, herbal compound Balanitin-6 a diosgenyl saponin, found in the bark and seed of Balanites aegyptiaca has been investigated as potential inhibitor of Plasmodium vivex didydrofolate reductase (PvDHFR) activity. Molecular interaction analysis using Ligplot, Chimera, and PyMol of Balanitin-6/PvDHFR complex have revealed three hydrogen bonds with(More)
Acquired immunodeficiency syndrome (AIDS) is a life threatening disease of the human immune system caused by human immunodeficiency virus (HIV). Effective inhibition of reverse transcriptase activity is a prominent, clinically viable approach for the treatment of AIDS. Few non-nucleoside reverse transcriptase inhibitors (NNRTIs) have been approved by the(More)
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