Chandra Thomas

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BACKGROUND Pneumococcal disease causes significant morbidity and mortality in at-risk individuals, and is complicated by emerging antibiotic resistance. An effective, safe and cost-effective vaccine is available, but despite this many patients who would benefit from pneumococcal vaccination remain unvaccinated. The purpose of this study was to determine the(More)
BACKGROUND Anti-angiogenic therapy targeted at vascular endothelial growth factor (VEGF) is now used to treat several types of cancer. We did a systematic review of randomized controlled trials (RCTs) to summarize the adverse effects of vascular endothelial growth factor inhibitors (VEGFi), focusing on those with vascular pathogenesis. METHODS AND(More)
The use of intelligent agents is proposed as an economical way to repurpose administrative data in order to foster a program of disease prevention in an outpatient context. A retrospective computerized search was conducted using administrative hospital discharge data to identify patients admitted to a medical teaching unit who met the Canadian Immunization(More)
BACKGROUND Guideline committees have identified the need for research to inform the provision of conservative care for older adults with stage 5 chronic kidney disease (CKD) who have a high burden of comorbidity or functional impairment. We will use both qualitative and quantitative methodologies to provide a comprehensive understanding of barriers and(More)
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