Chandhanee Itthipanichpong

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BACKGROUND Celecoxib, a nonsteroidal antiinflammatory drug exhibits its antiinflammatory effect by selective inhibition of cyclooxygenase-2 (COX-2) enzyme. Its efficacy has been accepted for the treatment of arthritic pain with superior gastrointestinal side effect profile compared with other conventional NSAIDs. OBJECTIVE To elucidate clinical(More)
Examination of chemical compositions of essential oil distilled from the fruit of Zanthoxylum limonella Alston (Rutaceae) revealed the presence of 33 chemical components. Evaluation of the oil composition was achieved by GC/MS analysis. Limonene (31.09%), terpin-4-ol (13.94%) and sabinene (9.13%) were found to be the major components. Effects of essential(More)
Curcuminoids, a yellow constituent isolated from Curcuma longa Linn. rhizomes was studied for its antispasmodic activity in isolated guinea-pig ileum and rat uterus. Curcuminoids at the concentration of 12 microg/ml significantly inhibited the ileum pre-contracted with acetylcholine (ACh) 5 x 10(-7) M and histamine 5 x 10(-7) M. (Force of contraction was(More)
Thunbergia laurifolia Lindl (TL) has been traditionally used as an antidote, anti-inflammatory, and anti-drug addiction. This study investigated the burn wound healing activity of TL leaf extract (TLL) from supercritical CO2 extraction in rats. The extract was prepared to 2.5%, 5%, and 10% gel (TLL gel). Rats were induced to second-degree burn wounds. They(More)
The effect of antacid on aspirin pharmacokinetics and bioavailability was determined in 10 healthy adult male and female volunteers, aged 20-45 years old. Each subject received 650 mg of aspirin orally after an overnight fast. The wash out period was 14 days and then all subjects were given 650 mg of aspirin 10 minutes after antacid (aluminium hydroxide and(More)
The pharmacological effect of 6-deoxyclitoriacetal (6-DA), a rotenoid compound isolated from the roots of Clitoria macrophylla Wall. (Papilionaceae), was examined on different smooth muscle preparations. 6-Deoxyclitoriacetal 0.2 mg/ml produced a significant decrease in the spontaneous contraction of isolated rat uterus. It also suppressed the contraction(More)
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