Chander Sadasivan

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Acetylcholinesterase hydrolyzes the neurotransmitter called acetylcholine and is crucially involved in the regulation of neurotransmission. One of the observable facts in the neurodegenerative disorders like Alzheimer's disease is the decrease in the level of acetylcholine. Available drugs that are used for the treatment of Alzheimer's disease are primarily(More)
It has been known for more than a decade that intracranial aneurysms can be successfully treated by deploying a porous meshed tube in the parent vessel of the aneurysm. Such devices are currently called flow diverters because they promote intraneurysmal flow stasis and thrombosis by diverting blood flow away from the aneurysm sac. The objective of this(More)
BACKGROUND AND PURPOSE Endovascular stent placement is an emerging technique in treating cerebral aneurysms. Thus far, no quantitative method is available to determine the effectiveness of stent deployment in reducing intraaneurysmal flow circulation, and thereby, in excluding the aneurysm from the cerebral vasculature. Our purpose was to develop a(More)
Many factors that are either blood-, wall-, or hemodynamics-borne have been associated with the initiation, growth, and rupture of intracranial aneurysms. The distribution of cerebral aneurysms around the bifurcations of the circle of Willis has provided the impetus for numerous studies trying to link hemodynamic factors (flow impingement, pressure, and/or(More)
Intracranial aneurysms are abnormal focal enlargements of the vascular walls that require immediate surgical intervention once detected. Emerging stent technology involves an innovative type of finely-braided stents, called flow diverters, which abruptly impede the arterial flow into the aneurysm, upon deployment, and induce thrombosis, vascular remodelling(More)
Fungal laccases are involved in a variety of physiological functions such as delignification, morphogenesis, and parasitism. In addition to these functions, we suggest that fungal laccases are involved in defense mechanisms. When the laccase secreting Trichoderma viride was grown in the presence of a range of microorganisms including bacteria and fungi,(More)
The anti inflammatory potential of the human and microbial biotransformed derivatives of berberine were determined by molecular docking. It was revealed that almost all derivatives formed as a result of biotransformation showed increase in phospholipase A2 binding affinity compared to berberine. The newly introduced -OH group/groups establish stronger(More)
Fatty acids have gained therapeutic attention because of their nutritional and health implications. The potentialities of different fatty acids as PLA2 binders have been analysed using molecular docking studies. Among the 46 fatty acids selected for docking studies, erucic acid and linoleic acid gave the highest glide scores. The earlier reported palmitic(More)
Acetylcholinesterase (AChE) is one of the crucial enzymes involved in nerve response and function. The loss of cholinergic activity is mainly characterized by the rapid hydrolysis of acetylcholine by AChE, which leads to a neurodegenerative disorder called Alzheimer’s disease (AD). Donepezil, an efficient inhibitor of AChE, is widely used in the therapy of(More)