Chandan Kumar

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Human DNA ligase1 (hLig1) is the major replicative enzyme in proliferating mammalian cells that join Okazaki fragments of the lagging strand during DNA replication. Interruptions in the process of ligation cause DNA damage to accumulate, resulting in cytotoxicity and cell death. In the present study we demonstrate that pyrrolo[1,4] benzodiazepine (PBD)(More)
  • Ravi P Kumar, M. B. Sreenivasa, +4 authors Andra Pradesha
  • 2013
Reinforced concrete multi-storied buildings are very complex to model as structural systems for analysis. The current version of the IS: 1893-2002 requires that practically all multi-storeyed buildings be analyzed as three-dimensional systems. This is due to the fact that the buildings have generally irregularities in plan or elevation or in both. Seismic(More)
DNA replication is a complex phenomenon that requires the concerted action of several enzymes, together with their protein and non-protein cofactors. In the nucleus, the two DNA strands are duplicated by two completely independent methods due to their anti-parallel orientation and the restrictive nature of DNA polymerases that allow DNA synthesis in the(More)
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