Chandan B. Mohanty

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OBJECT Cell therapy is a promising candidate among biological or technological innovations sought to augment microsurgical techniques in peripheral nerve repair. This report describes long-term functional regenerative effects of cell therapy in the rat injury model with a focus on sensory recovery. METHODS Schwann cells were derived from isogenic nerve or(More)
Increased production of neurotrophic factors (NTFs) is one of the key responses seen following peripheral nerve injury, making them an attractive choice for pro-regenerative gene therapies. However, the downside of over-expression of certain NTFs, including glial cell line-derived neurotrophic factor (GDNF), was earlier found to be the trapping and(More)
BACKGROUND Cervical spine sagittal malalignment has been demonstrated to correlate with the severity of disease in patients with cervical spondylotic myelopathy (CSM). The impact of spinal alignment on neurologic recovery has not been investigated thoroughly. The goal of this study was to evaluate the variable impact of preoperative sagittal alignment on(More)
The optimal refinement in nerve repair techniques has reached a plateau, making it imperative to continually explore newer avenues for improving the clinical outcome of peripheral nerve regeneration. The aim of this short review is to discuss the role and mechanism of brain plasticity in nerve regeneration, as well as to explore the possible application of(More)
Vein of Galen malformation (VOGM) is a rare congenital vascular anomaly, comprising about 1% of all intracranial vascular anomalies, predominantly affecting the children less than 1 year of age. A 6-month-old infant presented with complaints of increasing head size of 3 months duration and multiple episodes of vomiting associated with refusal to feed since(More)
STUDY DESIGN This is an ambispective analysis of a prospectively followed cohort of patients with cervical spondylotic myelopathy (CSM). OBJECTIVE The goal of this study was to evaluate the impact of sagittal alignment on magnetic resonance imaging (MRI) abnormalities in the cervical spinal cord as well as myelopathy severity in a prospective series of(More)