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The extent to which tissue-specific viral infections generate memory T cells specifically adapted to and maintained within the target infection site is unknown. Here, we show that respiratory virus-specific memory T cells in mice and humans are generated and maintained in compartmentalized niches in lungs, distinct from populations in lymphoid tissue or(More)
Lysinoalanine, N6-(DL-2-amino-2-carboxyethyl)-L-lysine, an unusual amino acid implicated as a renal toxic factor in rats, has been found in proteins of home-cooked and commercial foods and ingredients. Although it has been reported to occur in both edible and nonfood proteins only after alkali treatment, it has now been identified in food proteins that had(More)
The extent to which tissue-specific viral infections generate memory T cells specifically adapted to and maintained within the target infection site is unknown. Here, we show that respiratory virus-specific memory T cells in mice and humans are generated and maintained in compartmentalized niches in lungs, distinct from populations in lymphoid tissue or(More)
This work presents a boundary estimation approach for binary mixture fields based on a modified multi-layered neural network and front point approach. The boundary shape of anomaly is expressed with front points and the unknown front points are estimated with the proposed multi-layered neural network. Numerical experiments show that the proposed approach(More)
The rule extraction techniques have been widely developed and used for data mining in many application areas [1], such as medical diagnosis, decision-making, classification and prediction. Rough sets theory, proposed by Zdzislaw Pawlak in the early 1980's [2], has been used as rule extraction method for machine learning, knowledge discovery, expert systems(More)
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