Chan Kee Park

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PURPOSE The objective of this study was to determine whether transneuronal retrograde degeneration (TRD) of the retinal ganglion cells (RGCs) could be detected by optical coherence tomography (OCT) in humans with lesions other than of the occipital lobe or visual cortex. In addition, whether laterality and severity of retinal nerve fiber layer (RNFL) damage(More)
OBJECTIVE To confirm the advantages of the enhanced depth imaging (EDI) mode over the standard mode of the Heidelberg Spectralis spectral domain optical coherence tomography (SD-OCT) for imaging of the lamina cribrosa, and to compare laminar thicknesses of various glaucoma types with or without disc hemorrhage in a similar state of visual field loss. (More)
This study investigated whether endoplasmic reticulum (ER) stress induced retinal ganglion cell (RGC) death in chronic ocular hypertension, one of the RGC death mechanisms, using an experimental glaucoma rat model. Glaucoma was induced in adult male Sprague-Dawley rats by cauterizing three episcleral veins. The intraocular pressure (IOP) remained elevated(More)
Neuronal cells undergo apoptosis when deprived of neurotrophic factors due to injury, trauma, or neurodegenerative disease. This study examined cell death in the retina after chronic elevation of intraocular pressure (IOP) in an experimental rat model of human glaucomatous disease. Three episcleral veins on the ocular surface of rats were cauterized.(More)
PURPOSE To describe the results of a community-based eye screening program in Baltimore. DESIGN Cross-sectional study. METHODS This was a retrospective study of the results of screening both eyes of 5352 persons who presented at multiple community sites. The screening examination had eight risk factor questions, visual acuity measurement, and a(More)
Acute high IOP ischemia-reperfusion induces the loss of retinal ganglion cells, supporting the hypothesis that the condition of ischemia-reperfusion contributes to the induction and progression of glaucoma. This study investigated morphological changes, glial cell response, and expression of inducible nitric oxide synthase (iNOS) in the optic nerve head and(More)
BACKGROUND To compare the macular and peripapillary choroidal thickness between normal and glaucoma eyes and find out factors related to choroidal thickness using enhanced depth imaging (EDI) of Heidelberg Spectralis SD-OCT. STUDY DESIGN Cross-sectional transverse study. METHODS A total of 108 glaucoma patients and 48 healthy controls were included in(More)
OBJECTIVE To determine the diagnostic ability of laminar thickness obtained using enhanced depth imaging (EDI) of the Heidelberg Spectralis optical coherence tomography (OCT) system (Heidelberg Engineering, Heidelberg, Germany) and the factors related to laminar thickness in patients with glaucoma. DESIGN Evaluation of a diagnostic test. PARTICIPANTS A(More)
PURPOSE To evaluate the levels of TGF-β and lysyl oxidases in both the aqueous humor and in Tenon's tissue in patients with POAG, and to assess their association with bleb morphological features and outcomes of glaucoma surgery. METHODS Eighteen POAG patients scheduled to undergo glaucoma surgery and 17 healthy controls were enrolled. At the time of(More)
As an alternative to a viral vector, the application of stem cells to transfer specific genes is under investigation in various organs. Using this strategy may provide more effective method to supply neurotrophic factor to the neurodegenerative diseases caused by neurotrophic factor deprivation. This study investigated the possibility and efficacy of stem(More)