Chaminda Sellahewa

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BACKGROUND Both obesity and over-expression of HER II are associated with poor prognosis of breast cancer. In vitro experiments suggest that anti-tumour activity of the anti-obesity drug Orlistat is likely to be due to transcriptional suppression of HER II expression. The overexpression of HER II is also positively correlated with other markers of prognosis(More)
Although sporadic lipomas are not uncommon in the upper gastrointestinal tract, diffuse gastroduodenal lipomatosis is a rare clinical entity. Medical literature reveals a limited number of such cases presenting with upper gastrointestinal obstruction or bleeding. We present the management experience of a 43-year-old woman who presented with intussusception(More)
BACKGROUND The risk of nodal metastasis is higher in women with bigger breast. It is not clear if this increase is due to the size of the breast (largely related to obesity) or is the result of larger tumour size at presentation (due to delayed diagnosis). It is hypothesised that women with large breasts are more likely to have node positive disease mainly(More)
AIMS Dr. Foster Intelligence highlighted a higher than expected mortality rate from emergency Hartmann's procedure at a district general hospital from April 2007 to March 2009 (6.5% expected, 30% actual mortality). A retrospective audit of all Hartmann's procedures over 4 years was performed. METHODS Notes were examined for all emergency Hartmann's(More)
Background: Cholecystocutaneous fistula is a rare complication of chronic gallstone disease. We present a case of cholecystocutaneous fistula successfully managed with day-case laparoscopic cholecystectomy. Case Outline: An 80-year-old man initially presented with acute biliary sepsis, was treated conservatively, and later developed a right upper quadrant(More)
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