Chakravarthi Kanduri

Publications22
h-index10
Citations291
Highly Influential Citations7
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Genome-Wide Copy Number Variation Analysis in Extended Families and Unrelated Individuals Characterized for Musical Aptitude and Creativity in Music
Music perception and practice represent complex cognitive functions of the human brain. Recently, evidence for the molecular genetic background of music related phenotypes has been obtained. In order… Expand
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Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions
Combining HLA-DQ–gluten tetramers with mass cytometry and RNA sequencing analysis, we find that gluten-specific CD4+ T cells in the blood and intestines of patients with celiac disease display a… Expand
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The genome-wide landscape of copy number variations in the MUSGEN study provides evidence for a founder effect in the isolated Finnish population
Here we characterized the genome-wide architecture of copy number variations (CNVs) in 286 healthy, unrelated Finnish individuals belonging to the MUSGEN study, where molecular background underlying… Expand
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The landscape of copy number variations in Finnish families with autism spectrum disorders
Rare de novo and inherited copy number variations (CNVs) have been implicated in autism spectrum disorder (ASD) risk. However, the genetic underpinnings of ASD remain unknown in more than 80% of… Expand
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Hepatocyte-Specific Deletion of TIPARP, a Negative Regulator of the Aryl Hydrocarbon Receptor, Is Sufficient to Increase Sensitivity to Dioxin-Induced Wasting Syndrome
The aryl hydrocarbon receptor (AHR) mediates the toxic effects of dioxin (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin; TCDD), which includes thymic atrophy, steatohepatitis, and a lethal wasting syndrome… Expand
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The effect of listening to music on human transcriptome
Although brain imaging studies have demonstrated that listening to music alters human brain structure and function, the molecular mechanisms mediating those effects remain unknown. With the advent of… Expand
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The effect of music performance on the transcriptome of professional musicians
Music performance by professional musicians involves a wide-spectrum of cognitive and multi-sensory motor skills, whose biological basis is unknown. Several neuroscientific studies have demonstrated… Expand
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Colocalization analyses of genomic elements: approaches, recommendations and challenges
TLDR
We describe the different approaches and provide recommendations for performing genomic colocalization analysis, while also discussing common methodological challenges. Expand
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Coloc-stats: a unified web interface to perform colocalization analysis of genomic features
TLDR
We developed the Coloc-stats web server that provides a unified interface to multiple published methods of colocalization analysis across various analytical methods and method-specific options. Expand
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B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2
This study sheds light on the mechanism by which autoantibodies to transglutaminase 2 (TG2) are formed in celiac disease. The authors find that there is no deletion or silencing of autoreactive… Expand
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