Chak-Lam Cho

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Varicocele has been associated with reduced male reproductive potential. With the advances in biomolecular techniques, it has been possible to better understand the mechanisms involved in testicular damage provoked by varicocele. Current evidence suggests the central role of reactive oxygen species (ROS) and the resultant oxidative stress (OS) in the(More)
PURPOSE OF REVIEW The clinical utility of sperm DNA fragmentation tests needs to be revisited in light of increasing evidence of detrimental effect of sperm DNA damage on reproductive outcomes. RECENT FINDINGS Current evidence supports the association between high sperm DNA fragmentation and poor outcomes with regards to natural conception and(More)
The diagnosis of male infertility relies largely on conventional semen analysis, and its interpretation has a profound influence on subsequent management of patients. Despite poor correlation between conventional semen parameters and male fertility potential, inclusion of advanced semen quality tests to routine male infertility workup algorithms has not(More)
Reactive oxygen species (ROS) are present in low concentrations in the genital tracts of males and females. Excessive ROS lead to oxidative stress, which damages DNA, lipids and proteins. Such molecular changes result in compromised vitality, increased morphological defects and decreased sperm motility in the male. In the female, oxidative stress interferes(More)
BACKGROUND Sperm DNA fragmentation (SDF) testing has been recognized as a valuable tool in the evaluation of infertile men. Despite that, its routine use in clinical practice is still hampered by the lack of understanding of the specific clinical scenarios where SDF testing is most beneficial. The aim of this study was to investigate fertility specialists(More) © Translational Andrology and Urology. All rights reserved. The expert panel proposed a guideline on the clinical utility of sperm DNA fragmentation testing (1). Rapid advancement in the field of sperm DNA testing over the last two decades was summarized and structurally presented by the four clinical scenarios in an evidence-based(More)
Sperm DNA fragmentation (SDF) testing has been emerging as a valuable tool for male fertility evaluation. While the essential role of sperm DNA integrity in human reproduction was extensively studied, the clinical indication of SDF testing is less clear. This clinical practice guideline provides recommendations of clinical utility of the test supported by(More) © Translational Andrology and Urology. All rights reserved. Dr. Khandwala and Dr. Eisenberg in their insightful commentary discussed and endorsed the role of sperm DNA fragmentation (SDF) testing under specific circumstances in clinical practice (1). We concur with the authors that properly designed comparative studies, though ideal in(More)
Sperm DNA integrity is generally acknowledged as an essential component for human reproduction. While the negative impact of high sperm DNA fragmentation (SDF) on outcomes of natural pregnancy and assisted reproductive technology (ART) is well known, the clinical indication of SDF testing is less well defined. A recent review on clinical utility of SDF(More)
American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA; Division of Urology, Department of Surgery, Kwong Wah Hospital, Hong Kong, China; Department of Urology, Hamad Medical Corporation, Doha, Qatar; ANDROFERT, Andrology and Human Reproduction Clinic, Referral Center for Male Reproduction, Campinas, SP, Brazil Correspondence to:(More)