Chaitanya Krishna Murthy

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A sexually dimorphic distribution of galanin (GAL)-like immunoreactive (ir) neurons and fibers was found in the brain and pituitary of goldfish. The rostralmost GAL-ir perikarya were found in the area ventralis telencephali pars supracommissuralis dorsal to the anterior commissure. In the diencephalon, there was several GAL-ir perikarya in the nucleus(More)
The effects of gonadal steroids on the gonadotropin (GTH) release response to salmon gonadotropin-releasing hormone (sGnRH), chicken gonadotropin-releasing hormone-II (cGnRH-II), and the sGnRH analogue, [D-Arg6, Trp7, Leu epsilon, Pro9]-N-ethylamide-GnRH (sGnRH-A), were investigated using an in vitro perifusion system for goldfish pituitary fragments.(More)
The two native forms of GnRH, salmon GnRH and chicken GnRH-II, in the brain and pituitary of goldfish are both active in stimulating gonadotropin-II (GTH-II) and GH release. The objective of the present study was to characterize GnRH antagonists for their ability to inhibit sGnRH- and cGnRH-II-induced GTH-II and GH release in goldfish using a pituitary(More)
In goldfish, two native gonadotropin-releasing hormone (GnRH) peptides, salmon GnRH (sGnRH) and chicken-II GnRH (cGnRH-II), stimulate gonadotropin (GTH-II) and growth hormone (GH) secretion. In the present study we tested whether sGnRH and cGnRH-II act through different or the same population of GnRH receptors on GTH and GH cells, using various approaches.(More)
In goldfish, GnRH stimulates gonadotropin-II (GTH-II) and growth hormone (GH) release. The two native forms of GnRH, salmon GnRH (sGnRH) and chicken GnRH-II (cGnRH-II), bind to two classes of GnRH binding sites: high-affinity/low-capacity sites and low-affinity/high-capacity sites. Our previous in vitro perifusion studies of goldfish pituitary fragments(More)
In our previous in vitro studies, [Ac-delta 3-Pro1, 4FD-Phe2, D-Trp3,6]-mGnRH (analog E) suppressed both gonadotropin-II (GTH-II) and growth hormone (GH) release stimulated by sGnRH and cGnRH-II. In the present study analog E significantly inhibited the increases in plasma GTH-II levels stimulated by sGnRH in sexually mature female and sexually recrudescent(More)
The two native forms of gonadotropin-releasing hormones (GnRH) present in goldfish, salmon GnRH (sGnRH) and chicken GnRH-II (cGnRH-II), stimulate gonadotropin-II (GTH-II) and growth hormone (GH) release both in vivo and in vitro. In our previous study using perifused goldfish pituitary fragments, many mammalian GnRH antagonists, especially those with(More)
In goldfish the two native forms of gonadotropin-releasing hormone (GnRH), salmon GnRH (sGnRH) and chicken GnRH-II (cGnRH-II), stimulate both gonadotropin-II (GTH-II) and growth hormone (GH) release. Modifications of GnRH structure at positions 1, 2, 3, and 6 often result in an antagonist in goldfish, an observation well documented in mammalian studies. In(More)