Chack - Yung Yu

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The purpose of this study was to evaluate urine monocyte chemoattractant protein-1 (MCP-1) and IL-8 as biomarkers of SLE flare. Urine was collected every 2 mo from patients who were followed prospectively in the Ohio SLE Study. Renal and nonrenal flares were identified and MCP-1 and IL-8 were measured by specific ELISA in samples that were collected at(More)
The complement C4 locus is in the class III region of the MHC, and exhibits copy number variation. Complement C4 null alleles have shown association with a number of diseases including systemic lupus erythematosus (SLE). However, most studies to date have used protein immunophenotyping and not direct interrogation of the genome to determine C4 null allele(More)
OBJECTIVE Complement-mediated vasculopathy of muscle and skin are clinical features of juvenile dermatomyositis (JDM). We assess gene copy-number variations (CNVs) for complement C4 and its isotypes, C4A and C4B, in genetic risks and pathogenesis of JDM. METHODS The study population included 105 patients with JDM and 500 healthy European Americans. Gene(More)
Primate immune adherence receptors are erythrocyte complement receptors (E-CR) that favorably influence the clearance of circulating immune complexes (IC). The human E-CR is the type one complement receptor (CR1), most commonly expressed as a 220 kDa protein containing 30 short consensus repeats (SCRs). The chimpanzee E-CR is a 75 kDa protein composed of(More)
The complement system is part of the innate immune system and plays a role in regulating inflammation. Increased inflammation is engaged in the development of adult cardiometabolic diseases such as insulin resistance, dyslipidemia, atherosclerosis, and hypertension. Adipose tissue not only produces complement but is also a potential target for complement(More)
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