Chacha D Mangu

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BACKGROUND HIV-associated tuberculosis is difficult to diagnose and results in high mortality. Frequent extra-pulmonary presentation, inability to obtain sputum, and paucibacillary samples limits the usefulness of nucleic-acid amplification tests and smear microscopy. We therefore assessed a urine-based, lateral flow, point-of-care, lipoarabinomannan assay(More)
OBJECTIVES The relationship between cfu and Mycobacterial Growth Indicator Tube (MGIT) time to positivity (TTP) is uncertain. We attempted to understand this relationship and create a mathematical model to relate these two methods of determining mycobacterial load. METHODS Sequential bacteriological load data from clinical trials determined by MGIT and(More)
BACKGROUND As access to Xpert expands in high TB-burden settings, its performance against clinically diagnosed TB as a reference standard provides important insight as the majority of childhood TB is bacteriologically unconfirmed. We aim to describe the characteristics and outcomes of children with presumptive TB and TB disease, and assess performance of(More)
BACKGROUND An accurate biomarker is urgently needed to monitor the response to treatment in patients with pulmonary tuberculosis. The Xpert MTB/RIF assay is a commercially available real-time PCR that can be used to detect Mycobacterium-tuberculosis-specific DNA sequences in sputum samples. We therefore evaluated this assay with serial sputum samples(More)
BACKGROUND With one quarter of the world population infected, the intestinal nematode Ascaris lumbricoides is one of the most common infectious agents, especially in the tropics and sub-tropics. Infection is caused by oral intake of eggs and can cause respiratory and gastrointestinal problems. To identify high risk areas for intervention, it is necessary to(More)
BACKGROUND Hookworm disease is one of the most common infections and cause of a high disease burden in the tropics and subtropics. Remotely sensed ecological data and model-based geostatistics have been used recently to identify areas in need for hookworm control. METHODOLOGY Cross-sectional interview data and stool samples from 6,375 participants from(More)
SETTING Tanzania is a high-burden country for tuberculosis (TB), and prisoners are a high-risk group that should be screened actively, as recommended by the World Health Organization. Screening algorithms, starting with chest X-rays (CXRs), can detect asymptomatic cases, but depend on experienced readers, who are scarce in the penitentiary setting. Recent(More)
BACKGROUND The successful cure of tuberculosis (TB) is dependent on adherence to treatment. Various factors influence adherence, however, few are easily modifiable. There are limited data regarding correlates of psychological distress and their association with non-adherence to anti-TB treatment. METHODS In a trial of a new TB test, we measured(More)
SETTING Mbeya, Tanzania. OBJECTIVE To develop a new liquid culture method to detect Mycobacterium tuberculosis complex (MTC) in sputum using 2,3-diphenyl-5-thienyl-(2)-tetrazolium (STC), the nitrate reductase assay (NRA) and p-nitrobenzoic acid (PNB). DESIGN Ninety-three sputum samples collected from 18 tuberculosis patients were decontaminated with(More)
Grant Theron (grant.theron@uct.ac.za) Jonny Peter (jonny.g.peter@gmail.com) Lynn Zijenah (lzijenah@gmail.com) Duncan Chanda (duncanchanda@gmail.com) Chacha Mangu (cmangu@mmrp.org) Petra Clowes (pclowes@mmrp.org) Andrea Rachow (rachow@lrz.uni-muenchen.de) Maia Lesosky (lesosky@gmail.com) Michael Hoeslcher (hoelscher@lrz.uni-muenchen.de) Alex Pym(More)