Ch . Srinivas

Learn More
Endophytes are the chemical synthesizers inside plants and have been extensively investigated for their endophytic microbial complement. Different parts of Plumeria acuminata and Plumeria obtusifolia were subjected to the isolation of endophytic fungi and identified morphologically and also screened for antimicrobial activity against Staphylococcus aureus,(More)
The aim of the present study was to increase the solubility of a poorly water soluble BCS class II drug, valsartan. Liquisolid technology and solid dispersion by kneading method were techniques used to improve the solubility of the drug by using non-volatile solvents and some hydrophilic carriers. Liquisolid compacts were prepared by dissolving the drug in(More)
The first stereoselective total synthesis of new natural amide alkaloids 1-3 have been achieved from commercially available starting materials. Wittig olefination, Sharpless asymmetric dihydroxylation, epoxidation, a trans regioselective opening of 2,3-epoxy alcohol, Horner-Wadsworth-Emmons (HWE) olefination and amide coupling are the key steps. The amide(More)
Hepatocellular carcinoma (HCC) accounts for majority of liver cancers and is the leading cause of cancer related death in Asia. Like any other cancer, HCC develops when there is a mutation to the cellular machinery that causes the cell to replicate at a higher rate and results in the loss of apoptosis. Therefore, a delicate balance between the expression of(More)
Inventory management is very important area in the supply chain management. Excess stocks may lead to incurring holding costs while shortage of stocks lead to shortage costs. The problem becomes more complicated when several factories produce multiple products in multiple time periods and supplies to several distribution centers who in turn supply to(More)
Endophytic fungi found inside the plant tissue are endosymbionts, protecting their host from pests, pathogens, etc. Twenty eight endophytic fungi were isolated from different parts of Nerium oleander L., out of which, 54% of isolates were from flower, 39% from stem and 7% from leaf parts. Thirty six percent of the isolates showed antimicrobial activity(More)
  • 1