Ch. Karoff

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The effects of the loop diuretic piretanide on blood pressure and intra-erythrocytic free Na+ and Ca2+ were examined in 14 essential hypertensives. Intra-erythrocytic Ca2+ activity was found to decrease (P less than 0.01) and Na+ activity to increase (P less than 0.05). In spontaneously hypertensive rats (SHRs) hypovolaemia abolished the humoral(More)
In 16 essential hypertensives on a program of energy restriction (800 kcal/day) with and without simultaneous salt restriction, the effects on blood pressure and intracellular Na+ and Ca2+ in red blood cells were studied. A decrease in blood pressure and intracellular free Na+ and Ca2+ was only observed in the cases of simultaneous energy and salt(More)
In 12 moderately obese female probands without metabolic abnormalities, intracellular Mg++ activity, Na+ activity and Na+ concentration, and serum triglycerides, total cholesterol and HDL cholesterol were measured under a diet with fatty acids varying in the degree of saturation. During the diet with mainly saturated fatty acids the intracellular Na+(More)
A specific and sensitive radioimmunoassay of human vasoactive intestinal polypeptide using synthetic VIP as standard preparation and antiserum to synthetic VIP R 502 (Yanaihara et al. 15) is described. No crossreactions with a number of other gastrointestinal hormones such as glucagon, secretin, GIP, HPP or substance P was detected. Aprotinin (Trasylol,(More)
Intracellular activities of sodium and calcium were determined in red cells of patients with obesity. Compared to normal people mean intracellular sodium and calcium were higher in obese patients. However, increased intracellular sodium and calcium could only be observed in those patients with obesity suffering from hypertension or showing a familial(More)
Triglyceride-rich lipoproteins derived from ten normo- and hyperlipidemic apoE-2 homozygotes were analyzed for their composition, beta-VLDL content, and their ability to induce cholesteryl ester storage in macrophages. In six of these probands apoE sequence analysis revealed that the cysteine residues were at positions 112 and 158 of the amino acid sequence(More)