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In the yeast Saccharomyces cerevisiae genetic and biochemical evidence indicates that the product of the CDC25 gene activates the RAS/adenylyl cyclase/protein kinase A pathway by acting as a guanine nucleotide protein. Here we report the isolation of a mouse brain cDNA homologous to CDC25. The mouse cDNA, called CDC25Mm, complements specifically point(More)
The CDC25Mm gene codes for Ras-guanine nucleotide exchange factors. Four different full-length cDNA clones derived from the same gene and coding for proteins of different sizes that have in common the last 661 amino acids have been isolated from mouse brain. In order to investigate the expression of the products of this gene in different tissues we have(More)
CDC25Mm, a mouse Ras-Guanine nucleotide Exchange Factor, is specifically expressed as a product of 140 kDa (p140) in the postnatal and adult brain. Immunohistochemical analysis indicates that it is present throughout the brain particularly concentrated in discrete punctate structures. Subcellular fractionation of the mouse brain shows that p140 is present(More)
GDP-dissociation stimulators (GDSs) are the key element for the regeneration of the active state of ras proteins, but despite intensive investigations, little is so far known about their functional and structural properties, particularly in mammals. A growing number of genes from various organisms have been postulated to encode GDSs on the basis of sequence(More)
The anatomy of the pancreatic veins has become the object of renewed interest due to the advent of pancreatic phlebography coupled with selective blood sampling to diagnose the site of endocrine tumors of this organ. This study, based on the examination of 50 postmortem glands prepared by the technique of injection-corrosion, was undertaken to identify the(More)
The descriptive anatomy of the lateral thoracic wall and the topographical anatomy of the fifth intercostal space are used as bases for the description of the lateral approach to the thoracic cavity without muscle transection, considered by the authors as a “standard” approach to the thoracic cavity. Un rappel de l'anatomie descriptive de la paroi latérale(More)
A partir de travaux personnels et après une revue de la littérature les auteurs indiquent les impératifs anatomiques de la sphinctérotomie oddienne: - Le repérage de la papille tient compte de données anatomiques classiques, mais implique en pratique la mise en place d'une sonde palpable à travers la paroi duodénale. La duodénotomie sera horizontale pour(More)
segmentation portale de type adulte trbs precise et une segmentation sus-hEpatique moins marqu6e, comme en retard. Ainsi la segmentation portale parait-elle formde et entretenue uniquement par le sens et la force du courant sanguin ombilical gauche. Le flux ombilical en progressant de gauche ~t droite Emet et entretient les ramifications de la segmentation(More)
Pourl'anatomiste, la thoracotomie latérale sans section musculaire est une voie d'abord économique. Pourle chirurgien elle est d'exécution simple et rapide et procure une exposition très satisfaisante. Pourle malade, elle estconfortable (le patient ne repose pas sur ses drains et les mouvements de l'épaule ne sont pas douloureux)et esthétique. Enfin, pour(More)