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Real-time, in situ DNA hybridization detection with attomolar sensitivity without amplification using (pb(Mg1/3Nb2/3)O3)0.65-(PbTiO3)0.35 piezoelectric plate sensors.
In this paper we have investigated real-time, in situ DNA hybridization detection using piezoelectric plate sensors (PEPSs) consisting of a highly piezoelectric lead magnesium niobate-lead titanate… Expand
DNA hybridization detection with 100 zM sensitivity using piezoelectric plate sensors with an improved noise-reduction algorithm.
We have examined real-time, in situ hybridization detection of target DNA (tDNA) in a buffer solution and in urine using 8 μm-thick lead magnesium niobate-lead titanate (PMN-PT) piezoelectric plate… Expand
Specific in situ hepatitis B viral double mutation (HBVDM) detection in urine with 60 copies ml(-1) analytical sensitivity in a background of 250-fold wild type without DNA isolation and…
We have examined in situ detection of hepatitis B virus 1762T/1764A double mutation (HBVDM) in urine using a (Pb(Mg(1/3)Nb(2/3))O3)(0.65)(PbTiO3)(0.35) (PMN-PT) piezoelectric plate sensor (PEPS)… Expand
Temperature- and flow-enhanced detection specificity of mutated DNA against the wild type with reporter microspheres.
Detection of mutated (MT) deoxyribonucleic acid (DNA) amongst the wild type (WT) requires the probe DNA (pDNA) that is complementary to the MT to discriminate the WT by one or two nucleotide… Expand
Amplification-free in situ KRAS point mutation detection at 60 copies per mL in urine in a background of 1000-fold wild type.
We have examined the in situ detection of a single-nucleotide KRAS mutation in urine using a (Pb(Mg1/3Nb2/3)O3)0.65(PbTiO3)0.35 (PMN-PT) piezoelectric plate sensor (PEPS) coated with a 17-nucleotide… Expand
Rapid, label-free genetic detection of enteropathogens in stool without genetic isolation or amplification.
Current genetic detection methods require gene isolation, gene amplification and detection with a fluorescent-tagged probe. They typically require sophisticated equipment and expensive fluorescent… Expand
In situ, amplification-free double-stranded mutation detection at 60 copies/ml with thousand-fold wild type in urine.
- Ceyhun E. Kirimli, S. Lin, Y. Su, W. Shih, W. Shih
- Chemistry, Medicine
- Biosensors & bioelectronics
- 31 July 2018
We have investigated amplification-free in situ double-stranded mutation detection in urine in the concentration range 10-19 M - 10-16 M using piezoelectric plate sensors (PEPs). The detection was… Expand
Piezoelectric Plate Sensor (PEPS) for Analysis of Specific KRAS Point Mutations at Low Copy Number in Urine Without DNA Isolation or Amplification.
We have examined in situ detection of single-nucleotide KRAS mutations in urine using a (Pb(Mg1/3Nb2/3)O3)0.65(PbTiO3)0.35 (PMN-PT) piezoelectric plate sensor (PEPS) coated with a 17-nucleotide (nt)… Expand
In situ detection of transrenal gene mutations without DNA isolation and amplification using Array Piezoelectric Plate Sensor (PEPS)
- Ceyhun E. Kirimli
In situ detection of transrenal gene mutations without DNA i solation and amplification using Array Piezoelectric Plate Sensor (PEPS). Ceyhun E. Kirimli Wan Y. Shih, Ph. D. Wei-Heng Shih, Ph. D. Low… Expand
“Do It Yourself” Peristaltic Pump and Flowcell for QCM Biosensor
- İ. Çetin, Gorkem Yılmaz, Hande Halilibrahimoglu, Ceyhun E. Kirimli
- Materials Science
- 21st National Biomedical Engineering Meeting…
- 1 November 2017
The purpose of this study is to design and fabricate a doit- yourself (DIY) peristaltic pump and a flow cell for QCM biosensor. Expand