This paper presents an innovative tool and method that allow efficient innovation of shape and topology of virtual parts at both mesh and CAD levels using optimization methods. The method consists of automatic variations of shapes in CAD/CAE environments that allow effective search for new shapes that are not considered initially by designers.
Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplants (allo-HSCT) associated with significant morbidity and mortality. The earliest and most common manifestation is cutaneous graft-versus-host disease. This review focuses on the pathophysiology, clinical features, prevention and treatment of cutaneous… (More)