Cesar A Rodriguez

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BACKGROUND Taxanes are among the most active drugs for the treatment of metastatic breast cancer, and, as a consequence, they have also been studied in the adjuvant setting. METHODS After breast cancer surgery, women with lymph node-positive disease were randomly assigned to treatment with fluorouracil, epirubicin, and cyclophosphamide (FEC) or with FEC(More)
BACKGROUND We aimed to compare the additional benefit of gemcitabine when combined with vinorelbine above that of standard vinorelbine treatment in patients with metastatic breast cancer. METHODS In this phase III, multicentre, open-label, randomised study, 252 women with locally recurrent and metastatic breast cancer who had been pretreated with(More)
We comparatively evaluated different cytokeratin (CK) reagents analyzed by flow cytometry (FCM) for the identification of the best combination of DNA/CK staining for detecting minimal numbers of breast cancer cells in peripheral blood (PB). In 59 primary breast cancer tumors, we comparatively analyzed the reactivity for up to 6 different anti-CK reagents(More)
We integrate two compact data structures for representing state spaces of Petri nets: merged processes and contextual prefixes. The resulting data structure, called contextual merged processes (CMP), combines the advantages of the original ones and copes with several important sources of state space explosion: concurrency, sequences of choices, and(More)
The re-use of previously validated designs is critical to the evolution of synthetic biology from a research discipline to an engineering practice. Here we describe the Synthetic Biology Open Language (SBOL), a proposed data standard for exchanging designs within the synthetic biology community. SBOL represents synthetic biology designs in a(More)
Partial order reduction (POR) and net unfoldings are two alternative methods to tackle statespace explosion caused by concurrency. In this paper, we propose the combination of both approaches in an effort to combine their strengths. We first define, for an abstract execution model, unfolding semantics parameterized over an arbitrary independence relation.(More)
Treatment with fluororacil, epirubicin, and cyclophosphamide followed by weekly paclitaxel (FEC-P) yielded superior disease-free survival than FEC in the adjuvant breast cancer trial GEICAM 9906. We evaluate molecular subtypes predictive of prognosis and paclitaxel response in this trial. Two molecular subtype classifications based on conventional(More)
We carried out a mutational analysis of BRCA1 and BRCA2 genes in 103 individuals from a population in Western Central Spain and we identified nine new variants: two truncating mutations in BRCA2 [2604C>A (Y792X), 8873del4], three missense mutations in BRCA2 [677A>G (H150R), 958G>A (D224N) and 3398A>G (K1057R], and four silent mutations, two in BRCA1(More)
Cunf is a tool for building and analyzing unfoldings of Petri nets with read arcs. An unfolding represents the behaviour of a net by a partial order, effectively coping with the state-explosion problem stemming from the interleaving of concurrent actions. C-net unfoldings can be up to exponentially smaller than Petri net unfoldings, and recent work proposed(More)
Only a limited number of studies have evaluated the efficacy of 18F-FDG PET/CT for recurrent cervical carcinoma, which this study seeks to expand upon. This is a retrospective study of 30 women with cervical carcinoma who had a surveillance PET/CT after initial therapy. Sensitivity, specificity, accuracy, positive predictive value, and negative predictive(More)