Cesar A. López

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Computational modeling of biological systems is challenging because of the multitude of spatial and temporal scales involved. Replacing atomistic detail with lower resolution, coarse grained (CG), beads has opened the way to simulate large-scale biomolecular processes on time scales inaccessible to all-atom models. We provide an overview of some of the more(More)
Beta-cyclodextrins (β-CDs) can form inclusion complexes with cholesterol, and are commonly used to manipulate cholesterol levels of biomembranes. In this work, we have used multiscale molecular dynamics simulations to provide a detailed view on the interaction between β-CDs and lipid model membranes. We show that cholesterol can be extracted efficiently(More)
Impact evaluations aim to predict the future, but they are rooted in particular contexts and results may not generalize across settings. I founded an organization to systematically collect and synthesize impact evaluation results on a wide variety of interventions in development. These data allow me to answer this and other questions for the first time(More)
The depletion of cholesterol from membranes, mediated by β-cyclodextrin (β-CD) is well known and documented, but the molecular details of this process are largely unknown. Using molecular dynamics simulations, we have been able to study the CD mediated extraction of cholesterol from model membranes, in particular from a pure cholesterol monolayer, at atomic(More)
Impact evaluations aim to predict the future, but they are rooted in particular contexts and to what extent they generalize is an open and important question. I exploit a new data set of impact evaluation results on a wide variety of interventions in development to answer this and other questions. I find that while a good model and the separation of(More)
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