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BACKGROUND The efficacy and safety of certolizumab pegol (CZP) in moderate-to-severe Crohn's disease were demonstrated in two 26-week double-blind studies (PRECiSE 1 & 2). AIM To report the safety and efficacy outcomes of long-term, CZP therapy from PRECiSE 3, in which patients received treatment up to 7 years treatment. METHODS Patients completing(More)
Published reports of aorto-left atrial fistula are very rare. We report a 20-year-old man who had an aorto-left atrial fistula with bicuspid aortic valve and coronary artery origin anomaly. Because acquired etiologic factors were not detected, we believe that the lesions were structural defects of congenital origin.
BACKGROUND Patients with Crohn's disease in whom tumor necrosis factor antagonist therapy fails have limited treatment options, and the benefit of reintroducing the same therapy remains unclear. Here, we report results from PRECiSE 4 (NCT00160706), an open-label extension study of certolizumab pegol in patients who withdrew from the placebo-controlled(More)
OBJECTIVE The purpose of this study was to evaluate early findings for aortopulmonary shunts using bovine internal mammary artery grafting. METHODS Bovine internal mammary artery grafts biomodified with glutaraldehyde and the Shelhigh No-React process were used between May 2005 and April 2006 in our clinic for 20 cases of aorta-pulmonary artery shunts. We(More)
BACKGROUND Numerous surgical approaches have been reported for the repair of bronchopleural fistula. Recently the transsternal transpericardial approach has shown great promise with its positive results in cases of bronchopleural fistula complicated with empyema. The aim of this retrospective study was to assess the results of bronchopleural fistula(More)
Male patient with a history of high lateral myocardial infarction experienced 45 days before admission was accepted to our clinic with the initial diagnosis of congestive heart failure. Physical examination revealed 2-3 degrees/6 systolic murmur in the mesocardiac region. Telecardiography revealed a mass of 12 x 6 cms in the left hilus. Pseudoaneurysm was(More)
Atrial septostomy or septectomy are required to enable atrial mixture in various congenital cardiac lesions. The aim of this article was to introduce a technique where atrial septostomy application could be employed off pump with the aid of a new device. To our knowledge this is the first report for this technique in the literature. We report the results of(More)
To the Editor: In a recent meta-analysis, Ford et al. ( 1 ) reported results of an analysis of pooled data from randomized, controlled trials of anti-tumor necrosis factor (TNF) biological therapies in infl ammatory bowel disease (IBD), to determine relative risk (RR) of failure to achieve remission in active disease and RR of relapse of acti vity in(More)
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