Celio D. Angelis

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We studied killer-cell Ig-like receptor (KIR)/natural killer (NK)-cell group-2-Ag repertoires on donor-derived NK cells in 28 patients after haploidentical SCT in the first 6 months after SCT and correlated results with EFS. The reconstitution hierarchy of potentially alloreactive, single KIR+ NK cells was the following: HLA-C1 binding>HLA-Bw4(More)
Exceptional cases of histiocytic tumors have been described in patients with a history of acute lymphoblastic leukemia (ALL). Although the cells of the two lesions have different lineage origin, they often share identical clonal molecular markers. However, no definitive data about the molecular drivers of such phenotypic switches exist. Expression of the(More)
Upregulation of xanthine oxidoreductase (XOR) increases vascular reactive oxygen species (ROS) levels and contributes to nitroso-redox imbalance. However, XOR can generate nitric oxide (NO) from nitrite, and increased superoxide could inactivate NO formed from nitrite. This study tested the hypothesis that XOR contributes to the cardiovascular effects of(More)
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