Celine Osswald

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In the thymus, high-affinity, self-reactive thymocytes are eliminated from the pool of developing T cells, generating central tolerance. Here, we investigate how developing T cells measure self-antigen affinity. We show that very few CD4 or CD8 coreceptor molecules are coupled with the signal-initiating kinase, Lck. To initiate signaling, an antigen-engaged(More)
  • Citation Stepanek, Arvind S Ondrej, Celine Prabhakar, Carolyn G Osswald, Anna King, Dieter Bulek +20 others
  • 2015
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Summary In the thymus, high affinity, self-reactive thymocytes are eliminated from the pool of developing T cells, generating central tolerance. Here, we investigate how developing T cells measure self-antigen affinity. We show that very(More)
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